PMID: 6408125Jun 1, 1983Paper

Effect of very high dose D-leucine6-gonadotropin-releasing hormone proethylamide on the hypothalamic-pituitary testicular axis in patients with prostatic cancer

The Journal of Clinical Investigation
B WarnerR J Santen

Abstract

Potent synthetic analogs of gonadotropin-releasing hormone produce parodoxical antireproductive effects when administered chronically. These compounds are minimally toxic and may exhibit no plateau of the dose-response curve even at very high doses. These considerations served as the basis for our systematic evaluation of [D-leucine6-desarginine-glycine-NH2(10)]gonadotropin-releasing hormone (GnRH-A) proethylamide in the very high dose range (i.e., 10-fold larger amounts than previously used). In rats given the analog for 12 wk, prostate, testis, and seminal vesicle weights were suppressed to a greater extent with 200 micrograms q.d. than with 40 micrograms q.d. (P less than 0.01 prostate, less than 0.01 testis, less than 0.01 seminal vesicles), indicating dose-response effects in the very high dose range. 200 micrograms of [D-Leu6-des-Gly-NH2(10]-GnRH-A consistently suppressed leutinizing hormone (LH) values at 6 and 12 wk (basal 71 +/- 9.5; 6 wk 34 +/- 3.8; 12 wk 28 +/- 5 ng/ml) whereas 40 micrograms suppressed LH variably (basal 33 +/- 3.8; 6 wk 17 +/- 3.9; 12 wk 32 +/- 5.2). Testosterone fell to 15 +/- 2.4 and 19 +/- 2.0 ng/100 ml in response to 200 micrograms q.d. and to 27 +/- 6.4 and 22 +/- 7.4 ng/100 ml with the 40-micr...Continue Reading

References

Jul 1, 1979·Obstetrics and Gynecology·F T MurrayJ M Hammond
Jul 1, 1978·Acta Endocrinologica·J Sandow, M Hahn
Jul 1, 1976·Clinical Endocrinology·H W BakerG C Rennie
May 1, 1975·The Journal of Clinical Endocrinology and Metabolism·H E KulinA J Ferber
Jan 1, 1975·Journal of Surgical Oncology·D E JohnsonA G Ayala
May 1, 1976·The Journal of Clinical Endocrinology and Metabolism·M L DufauK J Catt
Nov 1, 1973·The Journal of Clinical Endocrinology and Metabolism·D R LondonJ M Stephenson
Jul 1, 1974·The Journal of Clinical Endocrinology and Metabolism·R RubensA Vermeulen
Mar 1, 1981·The Journal of Clinical Endocrinology and Metabolism·J GellerD Loza
Aug 1, 1980·The Journal of Clinical Endocrinology and Metabolism·G A BourneJ C Marshall
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R N ClaytonK J Catt
Jan 1, 1981·Endocrine Reviews·A J Hsueh, P B Jones
Sep 1, 1981·The Journal of Clinical Investigation·G TolisA V Schally
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T W Redding, A V Schally
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G TolisA V Schally
Sep 1, 1980·The Journal of Clinical Endocrinology and Metabolism·D SparrowJ W Rowe
Jan 1, 1981·Endocrine Research Communications·J Teodorczyk-InjeyanA Malkin
May 1, 1982·The Journal of Clinical Endocrinology and Metabolism·D R MeldrumH L Judd
Mar 1, 1982·Journal of Reproduction and Fertility·H M Fraser

❮ Previous
Next ❯

Citations

Jan 1, 1986·Breast Cancer Research and Treatment·R J SantenH Harvey
Jan 1, 1986·Journal of Steroid Biochemistry·I HuhtaniemiR Clayton
Apr 1, 1992·Baillière's Clinical Endocrinology and Metabolism·R S SwerdloffS Bhasin
Nov 15, 1984·The New England Journal of Medicine·UNKNOWN Leuprolide Study Group
Jan 20, 1991·The New England Journal of Medicine·P M Conn, W F Crowley
Jan 31, 1991·The New England Journal of Medicine·P CoenR Santen
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A V Schally, T W Redding
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A V SchallyJ I Paz-Bouza
Nov 1, 1992·British Journal of Urology·E D Crawford
Apr 1, 1988·The Journal of Clinical Investigation·R J UrbanM L Dufau
Jul 11, 1991·Journal of Endocrinological Investigation·L E BrackettR J Santen
Feb 6, 2014·The Journal of Steroid Biochemistry and Molecular Biology·David J HandelsmanAnn J Conway
Nov 22, 2005·Expert Opinion on Drug Delivery·Larry R Brown
Dec 1, 1996·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K InadaM Ogawa
Aug 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R T TurnerN H Bell
Mar 1, 1983·Clinics in Endocrinology and Metabolism·M J Cronin, W S Evans
Jan 1, 1989·Scandinavian Journal of Urology and Nephrology·F PeterssonM Hammar
Feb 1, 1987·Baillière's Clinical Endocrinology and Metabolism·M L Dufau, J D Veldhuis
Jan 1, 1987·The Journal of Urology·J A Smith
Jan 1, 1997·The Annals of Pharmacotherapy·E J Dole, M T Holdsworth
May 6, 1991·The Medical Journal of Australia·R P Jansen, E J Keogh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.