Effect of viagra on retinal vein diameter in AMD patients

Experimental Eye Research
Tatyana I MetelitsinaChengcheng Liu

Abstract

The aim of the present study was to investigate the effect of sildenafil citrate (viagra) on retinal venous diameter in patients with age-related macular degeneration (AMD). We investigated 14 male patients in a double-masked, randomized, placebo-controlled, crossover study. In each subject, one eye with typical non-exudative AMD fundus features was studied. Each of the subjects received 100 mg dose of sildenafil or matching placebo on two separate study visits. Monochromatic fundus photographs were obtained in the study eye before dosing and then 30, 90, 180 and 300 min later. Measurements of the diameter of the major retinal veins from digitized negatives were carried out using "Vessel map" static vessel analysis program (IMEDOS GmbH, Weimar, Germany). Statistical analysis of the data comparing the effect of sildenafil and placebo on venous diameters was performed using analysis of variance (ANOVA) for repeated measures. An analysis of variance (ANOVA) comparing the effects of sildenafil citrate and placebo on retinal vein diameters showed a significant interaction between time and treatment (P = 0.03). In comparison to placebo, sildenafil citrate produced a statistically significant vasodilatation of major retinal veins of 4...Continue Reading

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Citations

Jan 10, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Alan M Laties
Sep 3, 2008·The Journal of Sexual Medicine·Taymour Mostafa
Jul 25, 2009·Clinical & Experimental Ophthalmology·Nathan M Kerr, Helen V Danesh-Meyer
Apr 27, 2011·Acta Ophthalmologica·Yochai Z ShoshaniBarbara Wirostko
Mar 17, 2009·American Journal of Ophthalmology·Lili GrunwaldJuan E Grunwald
Mar 27, 2019·Scientific Reports·Glenn YiuChui Ming Gemmy Cheung
Aug 13, 2020·International Journal of Retina and Vitreous·Natasha Ferreira Santos da CruzEduardo A Novais
Dec 12, 2018·Eye and Vision·Asaf AchironZvia Burgansky-Eliash
Apr 4, 2021·Biomedicines·Eva AusóGema Esquiva
Jun 28, 2021·Survey of Ophthalmology·Supriya AroraJay Chhablani

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