Effect of virus-induced interferon on the antibody response of suckling and adult mice

European Journal of Immunology
F VignauxW H Fridman

Abstract

Continued administration of potent virally induced mouse interferon (IFN type I) preparations to suckling mice resulted in an inhibition of the primary antibody response to sheep erythrocytes (14-day-old mice). When slightly older suckling mice were immunized (17 days old), a delay (about 2 days) in the kinetics of the response was observed, but the amplitude of the response was similar in both control and IFN-treated animals. In adult mice, potent IFN preparations did not inhibit the antibody response under a variety of experimental conditions (different doses of IFN, schedules of treatment, routes of injection, times of assay). Although IFN does inhibit the in vitro antibody response, we conclude that under most experimental conditions, injection of IFN type I is not immunosuppressive in adult mice. When administered after immunization, IFN clearly enhanced the primary antibody response. It is of interest that IFN, a product of viral infection, enhances in vivo those components of the immune system that have been implicated in the host response to viral infections (i.e. delayed-type hypersensitivity, natural killer cell and macrophage activity, expression of lymphocyte membrane molecules), and, as is shown here, the primary a...Continue Reading

References

Nov 1, 1976·CRC Critical Reviews in Biochemistry·H M Johnson, S Baron
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I GresserE De Maeyer
May 1, 1978·Infection and Immunity·O StrannegårdH Persson
Apr 1, 1979·Cellular Immunology·A SenikH Wigzell
Oct 27, 1978·Biochimica Et Biophysica Acta·I Gresser, M G Tovey
Dec 1, 1977·Cellular Immunology·I Gresser
Feb 1, 1976·The Australian Journal of Experimental Biology and Medical Science·R J BoothJ Marbrook
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·P LindahlM Tovey
Nov 6, 1975·Nature·I GresserI Chouroulinkov
Apr 1, 1976·Infection and Immunity·R M Donahoe, K Y Huang
May 1, 1974·Cellular Immunology·G J ThorbeckeJ Vilcek
Oct 1, 1973·Die Naturwissenschaften·D GerickeP Chandra
Dec 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·W Braun, H B Levy
Feb 1, 1974·Journal of the National Cancer Institute·I GresserD Brouty-Boyé
Jul 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·M G ToveyI Gresser
Mar 13, 1980·Nature·E De Maeyer, J De Maeyer-Guignard

❮ Previous
Next ❯

Citations

Jun 1, 1984·European Journal of Clinical Microbiology·P J GrobM Fernex
Jan 20, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Scott E HensleyHildegund C J Ertl
Jan 7, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Eleonora AricòAnthony A Nash
Mar 1, 1995·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·F Belardelli
Jan 1, 1985·International Journal of Health Services : Planning, Administration, Evaluation·I Susser
Jan 1, 1986·CRC Critical Reviews in Biochemistry·M Rubinstein, P Orchansky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.