Effect of vitamin A deficiency on cardiovascular function in the rat

Canadian Journal of Physiology and Pharmacology
G L WrightB S Chertow

Abstract

Selected parameters of cardiovascular function were evaluated in vitamin A-deficient rats at 70 days of age. Resting heart rate was increased by an average of 100 bpm (21.4+/-2.7%), whereas resting systolic blood pressure was normal in vitamin A-deficient animals. The maximal contractile force developed per milligram weight of tissue by aortic rings excised from vitamin A-deficient animals was reduced in response to high potassium (-25.0+/-8.7%) and phorbol 12,13-dibutyrate (-36.8+/-8.4%) but was only slightly reduced in response to norepinephrine (-17.8+/-11.1%). Intimal rubbing to remove the endothelium had no effect on the loss in contractile responsiveness, and the relaxant response to acetylcholine was similar between control and vitamin A-deficient tissue groups. This suggests that the decrease in contractility of vascular smooth muscle from the vitamin A-deficient rats did not involve altered release of endothelium-derived vasoactive factors. Western blot analysis suggested a reduction in the protein levels of several differentiation markers including alpha-actin (-22%), calponin (-37%), desmin (-37%), and vinculin (-40%), whereas the level of PKCalpha was unchanged from control values. Our findings indicate a significan...Continue Reading

References

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Citations

Jul 23, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S-K MyungW K Bae
Aug 4, 2011·Biochimica Et Biophysica Acta·Eun-Jung RheeJorge Plutzky
Oct 2, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D DownieA A Sneddon
Feb 15, 2007·The British Journal of Nutrition·Liliana B OliverosMaría S Gimenez
Sep 14, 2007·International Journal of Food Sciences and Nutrition·Andréa RamalhoDanielle F Lento
Nov 5, 2003·Journal of Applied Physiology·P J RobinsonP D Paré

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