PMID: 2124124Aug 1, 1990Paper

Effect of vitamin A in enteral formulae for burned guinea-pigs

Burns : Journal of the International Society for Burn Injuries
K KuroiwaJ L Nelson

Abstract

A burned guinea-pig model (30 per cent body surface area) was used to study the effects of dietary vitamin A. Sixty-five female guinea-pigs were infused enterally via gastrostomy feeding tubes with identical formulate (175 kcal/kg/day, 20 per cent of calories as protein) containing varying amounts of vitamin A. Groups I, II, III and IV received formulae containing 0, 10,000 iu (approximately equivalent to the guinea-pigs' RDA), 50,000 iu (5 x RDA) and 250,000 iu (25 x RDA) of vitamin A per litre, respectively. After 14 days of tube feeding, the animals were killed. Group I animals had evidence of vitamin A deficiency including low haemoglobin levels, lower red blood cell counts and lower caecal mucosal weight. Findings of hypervitaminosis A were observed only in animals given the highest dose of vitamin A (25 x RDA). These were elevated serum alkaline phosphatase and complement C3 levels and enlarged adrenal glands. Group IV also showed defective cell-mediated immunity as reflected by reduced delayed cutaneous response to dinitrofluorobenzene. In a second experiment groups I, II, III and IV were given formulas containing 0, 1 x RDA, 5 x RDA, and 10 x RDA of vitamin A respectively for 14 days. Through postburn days 12 to 14 they...Continue Reading

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Citations

Jun 7, 2013·Journal of Burn Care & Research : Official Publication of the American Burn Association·Megan J NordlundNicole S Gibran
Dec 5, 2006·Burns : Journal of the International Society for Burn Injuries·N A BremnerJ D Watson
Oct 1, 1995·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·G PerroA Iron
Sep 29, 2009·Burns : Journal of the International Society for Burn Injuries·Jun FanLiang Ma
Sep 26, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Mette M Berger
May 31, 2008·Nutritional Neuroscience·Craig EvansDiane L Sparkes
Aug 30, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Mette M Berger
Sep 2, 1992·Journal of Wound Care·S M G McLaren

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