Effect of vitamin B12 and folic acid supplementation on biomarkers of endothelial function and inflammation among elderly individuals with hyperhomocysteinemia

Vascular Medicine
Suzanne C van DijkYvo M Smulders

Abstract

B-vitamin trials failed to demonstrate beneficial effects on cardiovascular outcomes, but hyperhomocysteinemia still stands out as an independent cardiovascular risk factor, particularly in elderly individuals. B-vitamins may influence early vascular dysfunction, such as endothelial dysfunction, or may have adverse effects, for example on inflammation. We investigated the effect of B-vitamins on endothelial function and inflammation within an interventional study. This study was conducted within the framework of the B-PROOF trial, which included 2919 hyperhomocysteinemic elderly individuals, who received daily vitamin B12 (500 μg) and folic acid (400 μg) or placebo for 2 years. Using an electrochemiluminescence platform, we measured intercellular adhesion molecule 1 (ICAM-1), vascular adhesion molecule 1 (VCAM-1), serum amyloid A (SAA), vascular endothelial growth factor (VEGF) and C-reactive protein (CRP) at baseline and follow-up in a subsample of 522 participants (271 intervention group; 251 placebo). Treatment effects were analyzed with ANCOVA. The participants had a mean age of 72 years, and 55% of them were male. At the 2-year follow-up, B-vitamins did not change the ICAM-1 (+36% change in the intervention group versus +3...Continue Reading

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Citations

Dec 16, 2016·Nutrition Reviews·Anna E Stanhewicz, W Larry Kenney
Jan 27, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Shalini Jamwal, Saurabh Sharma
May 10, 2019·Frontiers in Immunology·Ana María Ruiz-LeónRosa Casas
Jul 31, 2020·Current Neuropharmacology·Jerzy LeszekGjumrakch Aliev

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Methods Mentioned

BETA
X-ray

Clinical Trials Mentioned

NCT00696514

Software Mentioned

SPSS
SAS

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