Effect of vitamin B12 treatment on haptocorrin

Clinical Chemistry
Anne L MørkbakEbba Nexø

Abstract

Haptocorrin (HC) carries the major part of circulating cobalamin, but whether HC is altered on treatment with vitamin B12 remains unknown. Our study included 3 populations: a population of vegan men (n = 174; vegan population), of whom 63 were treated daily with 5 mg of oral vitamin B12 for 3 months; a group of patients with a previous methylmalonic acid (MMA) concentration >0.4 micromol/L (n = 140; population with suspected deficiency), of which 69 were treated with weekly vitamin B12 injections (1 mg) for 4 weeks; and a subgroup of participants in a vitamin B intervention study (n = 88; nondeficient population), of whom 45 were treated daily with 0.4 mg of oral vitamin B12 for 3 months. Total HC and holoHC were measured by ELISA. Cobalamin was measured by an intrinsic factor (IF)-based assay. Samples were collected at baseline and 3 months after start of treatment. Compared with baseline results for the 3 study populations, total HC and holoHC increased 30 pmol/L for every 100 pmol/L increase in cobalamin. After treatment with vitamin B12, holoHC (P <0.0001) and total HC (P <0.0001) increased significantly in the vegan population. Only holoHC increased in the population with suspected deficiency (P <0.0001), whereas no altera...Continue Reading

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Citations

Nov 8, 2008·QJM : Monthly Journal of the Association of Physicians·N Dali-Youcef, E Andrès
Dec 1, 2010·Expert Reviews in Molecular Medicine·D Sean Froese, Roy A Gravel
Aug 25, 2009·Molecular Genetics and Metabolism·D S FroeseR A Gravel
Nov 10, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Anne L MorkbakEbba Nexo
Mar 12, 2010·Molecular Genetics and Metabolism·D S FroeseR A Gravel
Apr 16, 2013·PloS One·Tore Forsingdal HardleiEbba Nexo
Jan 30, 2019·Journal of Inherited Metabolic Disease·D Sean FroeseMatthias R Baumgartner
Mar 8, 2019·International Journal of Food Sciences and Nutrition·Maria V Chandra-HioeJayashree Arcot
Jan 30, 2007·Clinical Chemistry·Ralph Carmel

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