Effect of Vitamin D and Calcium Supplementation in Patients with Systemic Lupus Erythematosus

Saudi Journal of Medicine & Medical Sciences
Abdullah G Al-KushiMohammed A Alarjah

Abstract

Systemic lupus erythematosus is a chronic autoimmune disease that increases the risk of suboptimal vitamin D levels. To determine the effects of vitamin D and calcium supplementation on disease activity, related immune markers and bone mineral density in patients with systemic lupus erythematosus. Eighty-one patients with systemic lupus erythematosus aged 20-70 years were recruited for this interventional study. Participants were enrolled into the following groups: no corticosteroid treatment (n = 21), corticosteroid treatment but without supplementation (n = 30) and corticosteroid treatment along with oral vitamin D and calcium supplementation (n = 30). Disease activity and laboratory parameters of all participants were measured at baseline and at 6 months. Bone mineral density was assessed using standardized dual-energy X-ray absorptiometry. At baseline, none of the patients had a normal vitamin D status. There were no significant correlations between vitamin D status and the studied immune markers or disease activity values before and after supplementation. After 6 months, patients who received supplementation showed significant (P = 0.002) improvements in bone mineral density. In addition, frequency of osteopenia decreased ...Continue Reading

Citations

Aug 7, 2019·Medicina·Hector Salazar-GonzalezRaquel Echavarria
Mar 17, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Stefano BerardiFrancesco Paolo Cantatore
Oct 27, 2020·Frontiers in Medicine·Barbara RuaroMaurizio Cutolo
Jan 12, 2021·Frontiers in Medicine·Barbara RuaroCosimo Bruni
Aug 12, 2019·Life Sciences·Rebeca Illescas-MontesVíctor J Costela-Ruiz

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SPSS

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Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

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