Effect of vitamin D deficiency on macrophage and lymphocyte function in the rat

Calcified Tissue International
S WientroubL M Wahl

Abstract

Vitamin D deficiency has pronounced growth retardation effects on the skeletal system. Because the immune system has been implicated in the regulation of bone metabolism, we examined the effect of vitamin D deficiency on the functional development of immune function in a rachitic rat model. Rats deprived of vitamin D3 both in utero and in postnatal life (-/-) had significantly reduced thymocyte or splenocyte [3H]-thymidine incorporation to mitogens and decreased macrophage chemotaxis when compared with vitamin D3-sufficient rats (+/+). Rats that were deficient in vitamin D3 only during in utero development (-/+) or during postnatal life (+/-) tended to have [3H]thymidine incorporation levels that were intermediate to those of the -/- and +/+ group. Similarly, the chemotactic response of macrophages from the +/- and -/+ groups was intermediate to that of the -/- and +/+ group, except at high concentrations of C5a in which there was an overlap with the +/+ group. Interestingly, secretion of soluble mediators, including interleukin 2 by lymphocytes and interleukin 1 and PGE2 by macrophages, was unaffected by vitamin D deficiency. These results suggest that vitamin D3 is essential for the normal development of certain biological re...Continue Reading

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Citations

Jan 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·C Johnsson, G Tufveson
Aug 1, 1995·Acta Paediatrica Japonica; Overseas Edition·E YenerS Mir
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Jan 15, 2016·PLoS Pathogens·Marcela Montes de OcaChristian R Engwerda
Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anja WittkeMargherita T Cantorna

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