Effect of vitamin D on all-cause mortality in heart failure (EVITA): a 3-year randomized clinical trial with 4000 IU vitamin D daily

European Heart Journal
Armin ZittermannJochen Börgermann

Abstract

Circulating 25-hydroxyvitamin D (25OHD) levels <75 nmol/L are associated with a nonlinear increase in mortality risk. Such 25OHD levels are common in heart failure (HF). We therefore examined whether oral vitamin D supplementation reduces mortality in patients with advanced HF. Four hundred HF patients with 25OHD levels <75 nmol/L were randomized to receive 4000 IU vitamin D daily or matching placebo for 3 years. Primary endpoint was all-cause mortality. Key secondary outcome measures included hospitalization, resuscitation, mechanical circulatory support (MCS) implant, high urgent listing for heart transplantation, heart transplantation, and hypercalcaemia. Initial 25OHD levels were on average <40 nmol/L, remained around 40 nmol/L in patients assigned to placebo and plateaued around 100 nmol/L in patients assigned to vitamin D. Mortality was not different in patients receiving vitamin D (19.6%; n = 39) or placebo (17.9%; n = 36) with a hazard ratio (HR) of 1.09 [95% confidence interval (CI): 0.69-1.71; P = 0.726]. The need for MCS implant was however greater in patients assigned to vitamin D (15.4%, n = 28) vs. placebo [9.0%, n = 15; HR: 1.96 (95% CI: 1.04-3.66); P = 0.031]. Other secondary clinical endpoints were similar betw...Continue Reading

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References

Feb 7, 2003·Journal of the American College of Cardiology·Armin ZittermannPeter Stehle
Apr 9, 2005·Drugs & Aging·Eric J MacLaughlinChester A Bond
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Jun 11, 2008·The American Journal of Clinical Nutrition·John F AloiaJames K Yeh
Apr 16, 2011·Public Health Nutrition·A Catharine Ross
May 6, 2011·European Journal of Heart Failure·Licette C Y LiuRudolf A de Boer
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Dec 16, 2011·The American Journal of Clinical Nutrition·Armin ZittermannSara Gandini
Jan 15, 2013·European Heart Journal·Armin ZittermannJochen Börgermann
May 29, 2013·International Journal of Laboratory Hematology·Armin ZittermannJochen Börgermann
Sep 24, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Josef StehlikUNKNOWN International Society for Heart and Lung Transplantation
May 3, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·A DalbeniP Delva
Jul 25, 2014·The American Journal of Clinical Nutrition·John A FordUNKNOWN RECORD Trial Group
Jan 11, 2016·Journal of Internal Medicine·I R ReidM J Bolland
Apr 9, 2016·Journal of the American College of Cardiology·Klaus K WitteMark T Kearney

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Citations

Jan 13, 2018·The Journal of Clinical Endocrinology and Metabolism·Eirik DegerudJutta Dierkes
Mar 17, 2018·Archives of Osteoporosis·Michaël R Laurent
Nov 20, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C MarquinaB de Courten
Jan 17, 2019·Endocrine Connections·Stefan PilzMarlene Pandis
Aug 9, 2019·Stroke; a Journal of Cerebral Circulation·Brian P BerghoutM Kamran Ikram
Dec 6, 2019·Journal of Animal Physiology and Animal Nutrition·Rafael V A ZafalonMarcio A Brunetto
Jan 3, 2020·Circulation Research·JoAnn E MansonUNKNOWN VITAL Research Group
Apr 30, 2019·Scandinavian Cardiovascular Journal : SCJ·Ting WangZhiqian Min
Jan 28, 2017·Current Atherosclerosis Reports·Kathleen ChinErin D Michos
Jul 12, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Meifang WuLiming Lin
Aug 12, 2020·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·L M G MeemsR A de Boer
Aug 29, 2020·Aging Clinical and Experimental Research·René Rizzoli
Nov 16, 2017·International Journal of Endocrinology·Adriana J van BallegooijenNicolas Verheyen
Feb 12, 2020·Journal of Clinical Medicine·Maria CallejoFrancisco Perez-Vizcaino
Sep 16, 2017·International Journal of Endocrinology·Armin Zittermann
Aug 20, 2018·European Journal of Nutrition·Richard M CubbonKlaus K Witte
Jan 27, 2019·Nutrients·Adriana J van BallegooijenMarc G Vervloet
Nov 14, 2019·International Journal of Molecular Sciences·Natasa CvetinovicJerneja Farkas
Aug 16, 2017·European Heart Journal·Rudolf A de BoerDirk J van Veldhuisen
Dec 21, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A ZittermannJ F Gummert
Dec 7, 2018·Critical Reviews in Food Science and Nutrition·Simona DraganConstantin Tudor Luca
Aug 2, 2018·Frontiers in Endocrinology·Stefan PilzArmin Zittermann
Jun 30, 2019·Cellular and Molecular Life Sciences : CMLS·Ting-Wei LeeTing-I Lee
Aug 14, 2019·BMJ : British Medical Journal·Yu ZhangAndrew Faramand
Jul 7, 2018·Clinical Hypertension·Babikir KheiriGhassan Bachuwa
Sep 10, 2020·International Journal of Molecular Sciences·Nejla Latic, Reinhold G Erben
Jan 26, 2021·Clinical Nutrition ESPEN·Melika Hajimohammadebrahim-KetabforoushZahra Vahdat Shariatpanahi
Jan 30, 2021·Journal of the American College of Cardiology·Erin D MichosLawrence J Appel
Mar 7, 2021·Journal of the American Pharmacists Association : JAPhA·Ashwaq A AwadhJohn C Gallagher
Aug 5, 2018·The American Journal of Medicine·Ambarish PandeyM Kyla Shea
Apr 4, 2021·International Journal of Molecular Sciences·Armin ZittermannStefan Pilz
Jan 6, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Fernando de la Guía-GalipiensoHelios Pareja-Galeano

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