Effect of vitamin D on ventricular remodelling in heart failure: a meta-analysis of randomised controlled trials

BMJ Open
Jin-Dong ZhaoHui-Feng Zhang

Abstract

The level of vitamin D is considered to be associated with the development and progression of heart failure (HF). However, it is still unclear whether supplementation of vitamin D could improve ventricular remodelling in patients with HF. This study aimed to systematically evaluate the influence and safety of additional vitamin D supplementation on ventricular remodelling in patients with HF. This study is a meta-analysis of randomised controlled trials (RCTs). The PubMed, EMBASE, CNKI, Cochrane library, Web of Science databases and grey literature were searched for RCTs regarding the effect of vitamin D on ventricular remodelling in patients with HF (from database creation to October 2017). RevMan V.5.3 software was employed for data analysis. Seven RCTs with a total of 465 patients, including 235 cases in the vitamin D group and 230 cases in the control group, were included. Left ventricular end-diastolic dimension (LVEDD), left ventricular ejection fraction (LVEF) and the incidence of adverse reactions. Compared with the control group, a decrease in the LVEDD (mean difference (MD)=-2.31 mm, 95% CI -4.15 to -0.47, p=0.01) and an increase in the LVEF (MD=4.18%, 95% CI 0.36 to 7.99, p=0.03) were observed in the vitamin D group....Continue Reading

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Citations

Apr 30, 2019·Scandinavian Cardiovascular Journal : SCJ·Ting WangZhiqian Min
Dec 29, 2020·British Journal of Community Nursing·Ehsan Khan
Aug 3, 2020·The Journal of Cardiovascular Nursing·Mohannad Eid Abu RuzAbed Almajeed Shajrawi
Apr 4, 2021·International Journal of Molecular Sciences·Armin ZittermannStefan Pilz
Jun 1, 2021·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Aryan NaghediNima Farshadi

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