Effect of Vitamin D Supplement on Mood Status and Inflammation in Vitamin D Deficient Type 2 Diabetic Women with Anxiety: A Randomized Clinical Trial

International Journal of Preventive Medicine
Siavash FazelianLeila Khajehali

Abstract

Vitamin D plays an important role in nervous health and depression. Vitamin D deficiency and anxiety affect diabetic status. The purpose of this study was to determine the effect of vitamin D supplementation on anxiety, depression, and inflammation in diabetic women with anxiety. In this randomized controlled trial, totally 51 women with type 2 diabetes (T2DM) and vitamin D deficiency were randomly allocated to receive one oral pearl of 50,000 IU vitamin D3 (26 women) or a placebo (25 women) fortnightly for 16 weeks. Anthropometric indices, sun exposure, dietary intake, depression, anxiety, and stress scores and biochemical biomarkers including high sensitivity C-reactive protein (hs-CRP) and interleukin-10 (IL-10) were measured at the baseline and after 16-week supplementation. Mean ± SD age of participant was 47.43 ± 9.57 years old. Baseline values were not different between the groups. Anxiety score changes were significantly lower in vitamin D group than the controls (P = 0.001). Within group comparison indicated that depression in supplement group with lower vitamin D levels was significantly reduced. Serum hs-CRP reduced (P = 0.01), while IL-10 concentrations increased (P = 0.04) in the intervention group. Vitamin D suppl...Continue Reading

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Citations

Oct 7, 2020·Journal of Women's Health·Eynav E AccorttCalvin J Hobel
Feb 13, 2021·International Journal of Environmental Research and Public Health·Hanan AlfawazNasser M Al-Daghri
Mar 2, 2021·Frontiers in Psychiatry·Nicholas G Norwitz, Uma Naidoo
Mar 20, 2021·Journal of Cosmetic Dermatology·Vildan ManavAyşe Esra Koku Aksu

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS
Random Allocation
Nutritionist IV

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