Effect of Vitamin D supplement use on serum concentrations of total 25OHD levels in elderly women

The Journal of Steroid Biochemistry and Molecular Biology
P B Rapuri, J C Gallagher

Abstract

Vitamin D(2) and D(3) are generally considered equipotent in humans. As Vitamin D(2) supplements are commonly used by elderly in United States, we determined the contribution of 25OHD(2) to the total serum 25OHD levels by HPLC in elderly women who reported taking Vitamin D(2) supplements (n = 56) and also in a group of randomly selected unsupplemented women (n = 60). In addition, we compared the total serum 25OHD measured by HPLC with competitive protein-binding assay (CPBA), a method routinely employed to measure Vitamin D status. A correlation of 0.91 (P < 0.001) was observed between the two methods for the serum total 25OHD measurement. The mean serum 25OHD level in Vitamin D(2) supplemented group was significantly higher than in unsupplemented group measured by HPLC (32 versus 28 ng/ml) and marginally higher measured by CPBA (33 vs. 31 ng/ml). Seventy eight percent of women taking Vitamin D(2) supplements had appreciable amounts of circulating 25OHD(2,) which constituted about 25 percent of their total serum 25OHD. It is also interesting to note that Vitamin D deficiency was less prevalent in elderly women taking Vitamin D(2) supplements (1.8%) compared to women not taking any supplements (12%).

References

Sep 1, 1976·Archives of Biochemistry and Biophysics·J A EismanH F DeLuca
Dec 1, 1971·The Journal of Clinical Endocrinology and Metabolism·J G Haddad, K J Chyu
Nov 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·L HummerC Christiansen
Nov 7, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P LipsM F Holick
Jan 5, 2002·Calcified Tissue International·L MargiloffB Dawson-Hughes
May 8, 2002·The Journal of Clinical Endocrinology and Metabolism·Prema B RapuriVera Haynatzka

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Citations

Jan 31, 2006·Journal of the American Academy of Dermatology·Deon Wolpowitz, Barbara A Gilchrest
Jun 28, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Lukasz PułaskiGrzegorz Bartosz
May 14, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Indra Ramasamy
May 24, 2013·The American Journal of Clinical Nutrition·Fatimah M YousefCynthia A Thomson

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