Effect of vitamin D supplementation on blood pressure parameters in patients with vitamin D deficiency: a systematic review and meta-analysis

Journal of the American Society of Hypertension : JASH
Liqin Shu, Kun Huang

Abstract

Evidence suggests that supplementation of vitamin D cannot decrease blood pressure in normal populations. However, in randomized controlled trials (RCTs) with vitamin D deficient participants (defined as baseline serum 25[OH]D levels <30 ng/mL or 50 nmol/L), this effect is inconsistent and under debate. Thus, we performed this systematic review and meta-analysis to evaluate whether vitamin D supplementation could affect blood pressure parameters in vitamin D-deficient subjects. The PubMed, Web of Science, ScienceDirect, and Cochrane library databases were searched. Extracted data were pooled as weighted mean differences with 95% confidence intervals to evaluate the effects. Subgroup analysis was further conducted according to the characteristics of included studies. Seven RCTs that contained 560 participants were included in our meta-analysis. The pooled weighted mean difference of peripheral diastolic blood pressure was -1.65 mm Hg (95% confidence interval: -3.05 to -0.25, I2 = 30.3%). No significant effect of vitamin D supplementation was found on other parameters. Subgroup analysis showed a significant decrease in peripheral systolic blood pressure and diastolic blood pressure in Asia, 8 weeks of intervention, and more than ...Continue Reading

Citations

Jun 12, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Kenneth LoYing-Qing Feng
May 22, 2019·Nutrients·Cecilia Villa-EtchegoyenGabriela Cormick
Oct 11, 2020·Nature Reviews. Cardiology·Pedro L ValenzuelaAlejandro Lucia
Apr 4, 2021·Nutrients·Lucía Melguizo-RodríguezRebeca Illescas-Montes

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