Effect of Vitamin D Supplementation on Glucose Control and Inflammatory Response in Type II Diabetes: A Double Blind, Randomized Clinical Trial

International Journal of Endocrinology and Metabolism
Mohammed E Al-SofianiDarius L Mason

Abstract

Diabetes mellitus (DM) and vitamin D deficiency are major health concerns around the world. Evidence suggests a possible role of vitamin D in improvement of insulin secretion and sensitivity. We assessed whether vitamin D supplementation could be used in vitamin D deficient-type II diabetes to improve glucose metabolism, components of metabolic syndrome (MetS) and specific inflammatory biomarkers. A double blind, randomized clinical trial was conducted in King Khalid University Hospital, Saudi Arabia to evaluate the effect of cholecalciferol supplementation on glycemic control, MetS components and specific inflammatory biomarkers including tumor necrosis factor-alpha (TNF-α), Interleukin (IL-6), leptin, adiponectin and vascular cell adhesion molecule-1 (VCAM-1). Twenty-two patients with type II diabetes with insulin resistance, glycated hemoglobin (HbA1c) ≥ 6 (42 mmol/mol) and serum 25(OH)D < 50 nmol/L were randomized using a computer program to receive either supplementation with cholecalciferol (5000 IU/day) or placebo for 12 weeks. The primary outcome was change in HbA1c levels from baseline. Median [IQR] 25(OH)D levels increased significantly in the vitamin D group as 58.1 [48, 67.3] nmol/L (P = 0.002). There was no signifi...Continue Reading

References

Jan 29, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ute ZeitzReinhold G Erben
Apr 25, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Begoña MaestroConsuelo Calle
Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Rosemary BlandMartin Hewison
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Sep 21, 2010·Diabetes & Metabolism·C GarciaH Mayaudon
Aug 9, 2011·European Journal of Epidemiology·Susanne MoebusKarl-Heinz Jöckel
Oct 18, 2011·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·K Michael HambidgeNancy F Krebs

❮ Previous
Next ❯

Citations

Nov 26, 2015·Archives of Physiology and Biochemistry·Zienab Alrefaie, Hossam Awad
Dec 10, 2015·Pediatric Research·Shimpei NiwaMitsuyoshi Urashima
May 1, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Tina JafariLeila Mahmoodnia
Jun 16, 2019·International Journal of Molecular Sciences·Sylwia WenclewskaAgnieszka Śliwińska
May 29, 2019·Climacteric : the Journal of the International Menopause Society·P P FerreiraE A P Nahas
Sep 30, 2016·International Journal of Endocrinology and Metabolism·Majid ValizadehHamid Reza Amir Moghadami
Oct 9, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Fatemeh ImanparastElnaz Abbasi
Oct 26, 2018·Frontiers in Endocrinology·Yuliia I Komisarenko, Maryna I Bobryk
Jan 17, 2020·Environmental Health and Preventive Medicine·AlJohara M AlQuaizShatha Ahmed Alduraywish
Nov 24, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M ChakhtouraG El Hajj Fuleihan
Jan 26, 2021·Clinical Nutrition ESPEN·Seyed-Amir Tabatabaeizadeh, Niayesh Tafazoli
Jun 15, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fatemeh DashtiAhmad Esmaillzadeh

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.