Effect of vitamin E on keratinocyte-modulation induced by lauroylsarcosine

Japanese Journal of Pharmacology
T ShimizuK Kuriyama

Abstract

The effect of vitamin E on the modulation of keratinocytes was studied in rats. A 1% lauroylsarcosine (LS) ointment caused skin erythema with keratinocyte-damage. A 30% vitamin E ointment markedly alleviated this erythema and protected keratinocytes from cell damage. Vitamin E (100 micrograms/ml) was also effective on LS (7.5 micrograms/ml)-induced proliferative reduction of cultured keratinocytes. On the other hand, ointment containing superoxide dismutase (SOD) (99,000 U/g) decreased the LS-induced erythema, suggesting that superoxide anion (O2-) produced from keratinocytes play an important role in the skin irritation. Indeed, LS induced O2- production from cultured keratinocytes. The O2- was significantly reduced by vitamin E and SOD, although vitamin E had no effects on O2- production in a xanthine-xanthine oxidase system, unlike the effect observed with SOD. These results indicate that vitamin E is an inhibitor of keratinocyte-modulation.

References

Jul 8, 1991·Biochimica Et Biophysica Acta·W SakamotoM Mino
Dec 10, 1972·The Journal of Vitaminology·M Kamimura
Mar 1, 1982·The Journal of Investigative Dermatology·P P BradleyG Rothstein

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Citations

Mar 30, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Thomas WelssKlaus R Schröder
Oct 12, 2012·Cutaneous and Ocular Toxicology·Makoto EmaJunko Nakanishi
Sep 7, 2011·Regulatory Toxicology and Pharmacology : RTP·Makoto EmaJunko Nakanishi

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