Effect of vitamin E on lead exposure-induced learning and memory impairment in rats

Physiology & Behavior
Nasrin KhodamoradiAbdolrahman Sarihi

Abstract

Chronic lead (Pb(2+)) exposure has been associated with learning and memory impairments, whereas vitamin E improves cognitive deficits. In this study, using a passive avoidance learning model in rats, we investigated the effects of vitamin E on Pb(2+) exposure-induced learning and memory impairments in rats. In the present study, 56 Wistar male rats (weighting 230-250g) were divided into eight groups (n=7). The Pb(2+) exposure involved gavages of lead acetate solution using three different doses (0.05%, 0.1%, and 0.2%) and the vitamin E consisted of three different doses (10, 25, 50μg/rat) for 30days. After the 30-day period, the rats were tested using a passive avoidance task (acquisition test). In a retrieval test conducted 48h after the training, step through latency (STL) and time in the dark compartment (TDC) were recorded. The statistical analysis of data was performed using ANOVA followed by Tukey's post hoc analysis. In all cases, differences were considered significant if p<0.05. The results of the present study showed that chronic exposure to high doses of Pb(2+) significantly increased both the number of trails required for learning and the TDC, whereas it decreased the STL in the passive avoidance test. Administrati...Continue Reading

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Citations

Dec 18, 2015·Annals of Occupational and Environmental Medicine·Hwan-Cheol KimYoung-Seoub Hong
Oct 16, 2015·Brain Research·Iraj SalehiAbdolrahman Sarihi
Apr 28, 2016·Archives of Environmental & Occupational Health·Sławomir KasperczykEwa Birkner
Dec 17, 2016·International Journal of Molecular Sciences·Patrizia AmbroginiAndrea Minelli
Jan 24, 2017·Canadian Journal of Physiology and Pharmacology·Mariam ShiriFarshid Etaee
Jan 10, 2020·Environmental Science and Pollution Research International·Guanghua MaoLiuqing Yang
Oct 2, 2020·Journal of Molecular Neuroscience : MN·Seyed Asaad KarimiAlireza Komaki
Feb 10, 2020·Environmental Science and Pollution Research International·Shumaila MumtazSaiqa Andleeb

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