Effect of vitamin E on learning and memory deficit in aged rats

Journal of Nutritional Science and Vitaminology
Hirokatsu TakatsuShiro Urano

Abstract

In order to verify whether vitamin E improves the cognitive impairment induced through aging, aged rats fed a vitamin E-supplemented diet had their learning and memory functions assessed in comparison with the aged rats fed a normal diet using a Morris water maze test. Although normal aged rats showed very poor learning ability concerning the place of a platform in the water maze apparatus, the aged rats fed the vitamin E-supplemented diet learned the place with a marked speed in only 5 trials. After old animals showed the maximum learning ability, they were kept in a normal atmosphere for 48 h without a trial followed by an assessment of their memory function using the same apparatus. The vitamin E-supplementation to aged rats resulted in marked retention of their maximum memory function, although normal aged rats showed a significant memory loss of about 60%. Pyrroloquinoline quinone (PQQ), which increases in the production of nerve growth factor, and protects neurons, had a similar effect on cognitive function to that of vitamin E in the aged rats. These results suggest that vitamin E may improve cognitive deficit caused through aging by not only its neuro-protecting effect but an antioxidant efficacy.

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Citations

Mar 26, 2016·Journal of Clinical Biochemistry and Nutrition·Nozomi KaneaiShiro Urano
Dec 18, 2015·Annals of Occupational and Environmental Medicine·Hwan-Cheol KimYoung-Seoub Hong
Oct 16, 2015·Brain Research·Iraj SalehiAbdolrahman Sarihi
Jul 23, 2015·Molecular Neurobiology·Francesco Visioli, Emma Burgos-Ramos
Jul 15, 2015·Bioscience, Biotechnology, and Biochemistry·Mitsugu AkagawaKazuto Ikemoto
Mar 18, 2015·Physiology & Behavior·Nasrin KhodamoradiAbdolrahman Sarihi
Dec 17, 2016·International Journal of Molecular Sciences·Patrizia AmbroginiAndrea Minelli
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Pamela V Martino AdamiLaura Morelli
Oct 25, 2013·Food & Function·Luana M ManossoAna Lúcia S Rodrigues
Oct 15, 2019·Nutritional Neuroscience·Rahebeh MahdiniaMahmoud Elahdadi Salmani
Jun 3, 2017·Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials·Kazuto IkemotoKazuo Mukai

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