Effect of Vortioxetine vs. Escitalopram on Sexual Functioning in Adults with Well-Treated Major Depressive Disorder Experiencing SSRI-Induced Sexual Dysfunction

The Journal of Sexual Medicine
Paula L JacobsenAnita Clayton

Abstract

Sexual dysfunction is common with serotonergic antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), and does not resolve in most patients. Vortioxetine, an antidepressant with a multimodal mechanism of action, has shown low rates of sexual dysfunction in previous major depressive disorder (MDD) trials. This study compared the effects of vortioxetine and escitalopram on sexual functioning in adults with well-treated MDD experiencing treatment-emergent sexual dysfunction (TESD). Participants treated with, and responding to, citalopram, paroxetine, or sertraline were randomized to switch to either vortioxetine (10/20 mg; n = 225) or escitalopram (10/20 mg; n = 222) for 8 weeks. Sexual function was assessed using the Changes in Sexual Functioning Questionnaire Short Form (CSFQ-14), and antidepressant efficacy was assessed using the Montgomery-Åsberg Depression Rating Scale (MADRS), Clinical Global Impressions (CGI) scale, and Profile of Mood States brief form (POMS-brief). Safety and tolerability were also assessed. The primary endpoint was change from baseline in the CSFQ-14 total score after 8 weeks of treatment. The MADRS, CGI, and POMS-brief were us...Continue Reading

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Citations

Feb 3, 2016·Current Psychiatry Reports·Anita H Clayton, Veronica Harsh
Aug 16, 2016·The Psychiatric Clinics of North America·Anita H ClaytonJennifer G Votta
May 4, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Michael E ThaseEduard Vieta
Apr 14, 2018·Women's Health·Rosemary Basson, Thea Gilks
Jul 6, 2017·The Cochrane Database of Systematic Reviews·Markus KoestersCorrado Barbui
Jul 27, 2018·Journal of Psychopharmacology·Michael Cronquist ChristensenDavid S Baldwin
Nov 21, 2018·Expert Opinion on Drug Discovery·Xenia GondaFrank I Tarazi
Jun 17, 2020·Andrologia·Ayodeji Folorunsho Ajayi, Roland Eghoghosoa Akhigbe
Nov 23, 2017·Depression and Anxiety·Michael R LiebowitzRita Hanover
Mar 17, 2020·The Medical Journal of Australia·Jody Rothmore
May 24, 2019·Journal of Clinical Medicine·Angel L MontejoJosé L Villegas
Mar 16, 2018·Current Psychiatry Reports·Veronica Harsh, Anita H Clayton
Oct 9, 2019·Journal of Clinical Medicine·Angel L MontejoLaura Montejo
Sep 6, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·María Santos-CasadoBernardo Santos-Ramos
Jun 14, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anja DvojkovicNela Pivac
Aug 13, 2017·Revista de psiquiatrí́a y salud mental·Estela SalagreEduard Vieta

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