PMID: 8587150Oct 1, 1995Paper

Effect of water deprivation on the disposition kinetics of enrofloxacin in camels

Journal of Veterinary Pharmacology and Therapeutics
R GavrielliA Glickman

Abstract

Concentrations of enrofloxacin equivalent activity were determined (by microbiological assay) in the serum of normal camels and camels at the end of a 14-day water-deprivation period following single intravenous (i.v.), intramuscular (i.m.) and subcutaneous (s.c.) administrations at 2.5 mg/kg. Also, normal camels were given an oral drench of the drug at 5 mg/kg. Pharmacokinetic variables were determined using compartmental and non-compartmental analytical methods. Camels lost on average 12.5% of body weight at the end of the water-deprivation period. The disposition kinetics of i.v. administered drug in normal and water-deprived camels were very similar. The t1/2 beta was 3.0-3.5 h; MRT was 4.0-4.5 h; Vc was 0.3 L/kg; Vss was 1.0 L/kg and ClB was 4.0-4.6 mL/min/kg. The effect of water deprivation on the rate of drug absorption and elimination after i.m. administration was inconsistent, and there was also a large degree of variability in the normal animals that precluded statistical significance. After s.c. administration, the mean absorption half-life (t1/2abs) in the water-deprived camels was significantly longer than in the normal camels. Systemic availability (F) was similar in both normal and water-deprived camels after i.m...Continue Reading

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Citations

May 3, 2003·Research in Veterinary Science·A HaritovaD Pashov
Sep 1, 1996·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·B H AliA K Bashir
Aug 7, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K Abo El Sooud
Dec 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·J M ChristensenN Hollingshead
Feb 23, 2007·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·A Rae GandolfMark W Atkinson
Oct 7, 2005·Journal of Veterinary Pharmacology and Therapeutics·A GaurS P S Saini
Jul 31, 2003·Journal of Veterinary Pharmacology and Therapeutics·K JanusZ Muszczynski
Nov 10, 2007·Journal of Veterinary Pharmacology and Therapeutics·A M Abd El-AtyJ-H Shim
Sep 9, 2006·Journal of Veterinary Pharmacology and Therapeutics·I MahmoodR P Hunter
Jun 7, 2005·American Journal of Veterinary Research·A Rae GandolfMark W Atkinson
Jan 13, 2006·Biopharmaceutics & Drug Disposition·Soo K BaeMyung G Lee
Nov 26, 2015·Veterinary Medicine and Science·Prashant S DaundkarSuresh K Sharma

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