Effect of water on the surface molecular mobility of poly(lactide) thin films: an atomic force microscopy study

Biomacromolecules
Yoshihiro KikkawaYoshiharu Doi

Abstract

Physical properties associated with molecular mobility on the surface of thin films with 300 nm thickness for poly(lactide)s (PLAs) were studied under vacuum conditions as well as under aqueous conditions by using friction force mode atomic force microscopy (AFM). Two types of PLAs were applied for the experimental samples as uncrystallizable PLA (uc-PLA) and crystallizable PLA (c-PLA). The friction force on the surface of thin films was measured as a function of temperature to assess the surface molecular mobility both under vacuum and under aqueous conditions. A lower glass-transition temperature of the uc-PLA surface in water was detected than that under vacuum conditions. In the case of the c-PLA thin film, change in friction force was detected at a lower temperature under aqueous conditions than in vacuo. A morphological change was observed in the c-PLA thin film during heating process from room temperature to 100 degrees C by temperature-controlled AFM. The surface of the c-PLA thin film became rough due to the cold crystallization, and the crystallization of c-PLA molecules in water took place at a lower temperature than in vacuo. These friction force measurements and AFM observations suggest that molecular motion on the...Continue Reading

References

Apr 1, 1996·Journal of Biomedical Materials Research·Y IkadaE Fukada
Mar 13, 2002·Biomacromolecules·Yoshihiro KikkawaYoshiharu Doi

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Citations

Apr 2, 2016·Molecular Pharmaceutics·Hanying LuoMargarita Herrera-Alonso
Dec 3, 2020·Frontiers in Microbiology·Clodagh M CarrAlan D W Dobson
Jun 5, 2021·Journal of Chemical Information and Modeling·Sergio BonetaVicent Moliner

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