Effect of Water-Soluble Echinochrome Analog on Arrhythmia Severity in Experimental Model of Acute Myocardial Ischemia

Bulletin of Experimental Biology and Medicine
Olesya G BernikovaYa E Azarov

Abstract

The effects of therapeutic or preventive-therapeutic administration of water-soluble echinochrome analog U-441 on arrhythmia severity assessed by a set of myocardial spatio-temporal depolarization and repolarization parameters were examined on the model of acute myocardial ischemia in cats. Coronary occlusion increased activation time and decreased repolarization time in the ischemic zone; in addition, it increased both global and borderline (local) dispersions of repolarization. The linear regression model showed that only activation time values measured at the initial state and at termination of occlusion were associated with total arrhythmia score during ischemia (regression coefficient β=0.338, 95%CI=0.074-0.602, p=0.015 and β=0.720, 95%CI=0.323-1.117, p=0.001, respectively). The study revealed no association between administration of echinochrome analog U-441 and arrhythmia severity.

References

Mar 27, 2004·Physiological Reviews·André G Kléber, Yoram Rudy
May 13, 2011·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·O G BernikovaD N Shmakov
Jan 20, 2015·Journal of Electrocardiology·Ksenia SedovaSergey Kharin
Jan 15, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Olujimi A AjijolaKalyanam Shivkumar

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Citations

Dec 19, 2019·International Journal of Molecular Sciences·Ksenia A SedovaJan E Azarov
Jan 7, 2020·Chemical & Pharmaceutical Bulletin·Dmitry Aminin, Sergey Polonik
Aug 27, 2021·Marine Drugs·Hyoung Kyu KimJin Han

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