Effect of weight change on progression of knee OA structural features assessed by MRI in overweight and obese women

Osteoarthritis and Cartilage
M L A LandsmeerJ Runhaar

Abstract

To evaluate the effects of weight change on progression of knee osteoarthritis (OA) structural features by magnetic resonance imaging (MRI) in overweight and obese women without clinical knee OA. 347 participants from the Prevention of Knee Osteoarthritis in Overweight Females (PROOF) study were classified with latent class growth analysis into a subgroup with steady weight (n = 260; +0.1 ± 4.0 kg, +0.2 ± 4.4%), weight gain (n = 43; +8.6 ± 4.0 kg, +9.8 ± 4.1%) or weight loss (n = 44; -9.0 ± 7.2 kg, -9.8 ± 7.5%) over 2.5 years. Baseline and follow-up 1.5T MRIs were scored with MRI Osteoarthritis Knee Score (MOAKS) for progression of bone marrow lesions (BMLs), cartilage defects, osteophytes, meniscal abnormalities, meniscal extrusion and synovitis. Associations between subgroups and change in MRI features at knee-level were assessed using adjusted Generalized Estimating Equations. 687 knees from 347 women (median age 55.2 years, interquartile range (IQR) 5.5, median body mass index (BMI) 31.2 kg/m2, IQR 5.3) were analyzed. Progression of synovitis was 18% in the weight gain vs 7% in the stable weight subgroup (OR 2.88; 95%CI 1.39-5.94). The odds for progression of patellofemoral (PF) BMLs and cartilage defects increased with 62%...Continue Reading

Citations

Sep 26, 2020·Therapeutic Advances in Musculoskeletal Disease·Jorge A Roman-BlasGabriel Herrero-Beaumont
Nov 11, 2019·Rheumatology International·Harvi F HartSita Bierma-Zeinstra
Jan 17, 2021·Scientific Reports·Amber T CollinsCourtney M Karner
Feb 3, 2021·Journal of Vascular and Interventional Radiology : JVIR·Tijmen A van ZadelhoffEdwin H G Oei
Dec 18, 2020·Orthopaedic Journal of Sports Medicine·Amber T CollinsLouis E DeFrate
Dec 27, 2019·Osteoarthritis and Cartilage·R KijowskiA Guermazi
Jun 24, 2021·Orthopaedic Journal of Sports Medicine·Ding-Yu WangJia-Kuo Yu

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