Effect of Weight Loss Medications on Hepatic Steatosis and Steatohepatitis: A Systematic Review.

Frontiers in Endocrinology
Chelsea S Pan, Takara L Stanley

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a common comorbidity in individuals with obesity. Although multiple pharmacotherapeutics are in development, currently there are limited strategies specifically targeting NAFLD. This systematic review summarizes the existing literature on hepatic effects of medications used for weight loss. Glucagon-like peptide 1 (GLP-1) agonists are the best-studied in this regard, and evidence consistently demonstrates reduction in liver fat content, sometimes accompanied by improvements in histological features of steatohepatitis and reductions in serum markers of hepatic injury such as alanine aminotransferase (ALT). It remains unclear whether these benefits are independent of the weight loss caused by these agents. Literature is limited regarding effects of orlistat, but a small number of reports suggest that orlistat reduces liver fat content and improves histologic features of NASH, benefits which may also be driven primarily by weight loss. A sizeable body of literature on hepatic effects of metformin yields mixed results, with a probability of modest benefit, but no consistent signal for strong benefit. There are insufficient data on hepatic effects of topiramate, phentermine, naltrexone, b...Continue Reading

References

Feb 28, 2004·Alimentary Pharmacology & Therapeutics·A UygunK Dagalp
Jul 1, 2004·Alimentary Pharmacology & Therapeutics·S NairR P Perrillo
Jul 14, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·D MagalottiM Zoli
Sep 9, 2004·Alimentary Pharmacology & Therapeutics·S A HarrisonP Hayashi
Apr 2, 2005·Alimentary Pharmacology & Therapeutics·J B SchwimmerJ E Lavine
Apr 22, 2005·The American Journal of Gastroenterology·Elisabetta BugianesiGiulio Marchesini
Apr 25, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shira Zelber-SagiRan Oren
May 12, 2007·Journal of Diabetes and Its Complications·Ildiko LingvayLidia S Szczepaniak
Jun 11, 2008·Archives of Internal Medicine·Bankole A JohnsonUNKNOWN Topiramate for Alcoholism Study Group
Jul 18, 2008·Epidemiology·John P A Ioannidis
Oct 24, 2008·Alimentary Pharmacology & Therapeutics·R LoombaJ H Hoofnagle
Dec 5, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephen A HarrisonBrent A Neuschwander-Tetri
Jul 7, 2009·Journal of Diabetes and Its Complications·Alok K GuptaSteven R Smith
Aug 12, 2009·European Journal of Gastroenterology & Hepatology·Ziya OmerUlus Akarca
Oct 9, 2009·Scandinavian Journal of Gastroenterology·John Willy HaukelandKåre Birkeland
Nov 20, 2009·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·T KatoM Itoh
Feb 25, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G A GarinisA Belfiore
Feb 27, 2010·Obesity·Jonathan KrakoffUNKNOWN Diabetes Prevention Program Research Group
Apr 30, 2010·The New England Journal of Medicine·Arun J SanyalUNKNOWN NASH CRN
Apr 28, 2011·JAMA : the Journal of the American Medical Association·Joel E LavineUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jul 13, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dawn M TorresStephen A Harrison
Aug 13, 2011·The Journal of Clinical Endocrinology and Metabolism·Mira AubuchonUNKNOWN Reproductive Medicine Network
Jul 18, 2012·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Ildiko LingvayLidia S Szczepaniak
Nov 24, 2012·The Journal of Clinical Endocrinology and Metabolism·D KendallC Hall
Jan 10, 2014·Arquivos brasileiros de endocrinologia e metabologia·Hui FanXinChun Yang
Feb 12, 2015·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E SoiferM Shargorodsky
Sep 24, 2015·Journal of Hepatology·Matthew J ArmstrongJeremy W Tomlinson
Dec 29, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiMark Wymer

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

FibroScan
Orlistat

Related Concepts

Related Feeds

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.