Effect of weight loss on maximal fat oxidation rate in obese men

Obesity Research & Clinical Practice
Takehiko TsujimotoKiyoji Tanaka

Abstract

The hallmark features of obesity include insulin resistance and an impaired ability to oxidize lipids. As compared to exercise training, it remains relatively unclear if diet-induced weight loss can also induce fat metabolism. This study was undertaken to examine the effects of diet-induced weight loss on fat metabolism during a single session of exercise in middle-aged obese men. Fifteen obese men who were otherwise healthy (average age of 53.5 ± 6.9 yr and average body mass index of 27.8 ± 1.6 kg/m(2)) participated in a 12-wk weight loss program primarily consisting of dietary modification. Maximal fat oxidation (MFO) rates, MFO per lean body mass (MFOLBM) and insulin resistance (HOMA-IR) were measured before and after the program. Participants performed a 24-min graded exercise test on a cycle ergometer, with 15-W increments every 4 min. Expired gas analysis was performed by indirect calorimetry, and nonprotein respiratory quotient equations were used to calculate fat oxidation rates. The weight (-8.3 ± 3.8 kg), fat mass (-4.5 ± 1.9 kg), and lean body mass (-3.8 ± 2.4 kg) (P < 0.001 for all measurements) of the participants were decreased at the end of the 12-wk program. The MFO tended to increase by 19% (P = 0.08) and MFOLB...Continue Reading

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Citations

Dec 20, 2013·Scandinavian Journal of Medicine & Science in Sports·M RosenkildeB M Stallknecht
May 27, 2017·Journal of Applied Physiology·Sune DandanellJørn Wulff Helge
Jun 8, 2018·Frontiers in Physiology·Ed MaunderAndrew E Kilding
Mar 2, 2021·Frontiers in Physiology·Francisco J Amaro-GaheteDavid Jiménez-Pavón
Jul 27, 2021·European Journal of Sport Science·Juan Corral-PérezJesús G Ponce-González

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