Effect of weight reduction on serum ghrelin and TNFalpha concentrations in obese women

European Journal of Internal Medicine
Barbara Zahorska-MarkiewiczJoanna Janowska

Abstract

Background: Ghrelin causes weight gain by increasing food intake in rodents. Tumor necrosis factor alpha (TNFalpha) is produced by adipose tissue, modulates its metabolism and stimulates catabolic processes. The aim of our study was to evaluate whether weight loss treatment modulates serum concentrations of TNFalpha and ghrelin in obese women. Methods: The study groups included 46 women: 35 obese patients and 11 controls. Serum concentrations of ghrelin and TNFalpha were measured by ELISA before and after a 3-month weight reduction treatment that consisted of a 1000 kcal/day diet and physical exercises. Body composition was determined by impedance analysis using Bodystat. Results: There were no differences in plasma ghrelin concentrations between obese patients and controls. TNFalpha serum levels were higher in obese patients than in controls (p=0.000). The mean weight loss over the 3-month treatment period was 8.7+/-4.5 kg. Following weight loss, serum ghrelin concentration increased significantly (66.3+/-13.7 vs. 73.7+/-14.8 pg/ml; p=0.002) and TNFalpha concentrations decreased significantly (6.9+/-2.6 vs. 5.2+/-1.5 pg/ml; p=0.002). Ghrelin did not show a correlation with weight or percentage of body fat. There was a positive...Continue Reading

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Citations

Feb 2, 2010·Journal of Physiology and Biochemistry·Y OzkanI Sahin
Aug 9, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L DavidsenA Astrup
Mar 13, 2010·Mediators of Inflammation·Konstantinos TziomalosApostolos I Hatzitolios
Jul 31, 2012·International Journal of Endocrinology·Piotr KocełakMagdalena Olszanecka-Glinianowicz
Sep 23, 2008·Clinical Endocrinology·Ayse Kubat UzumNese Colak Ozbey
May 27, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M R DruceS R Bloom
Apr 14, 2006·Hormone Research·Alev E AltinovaMetin Arslan
Mar 12, 2008·The British Journal of Nutrition·Wokadala Cuthbert ObiroBo Jiang
Mar 16, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Angelo TremblayDavid Thivel
Jul 20, 2007·Journal of the American College of Nutrition·Sylvia SantosaPeter J H Jones
Jun 17, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paul S MacleanMatthew R Jackman
Jul 15, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Ayoub SaeidiHassane Zouhal

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