Effect of wheat gluten on improved thermal cross-linking and osteogenesis of hydroxyapatite-gelatin composite scaffolds.

International Journal of Biological Macromolecules
Lalitha Sri RamakrishnanManitha B Nair

Abstract

Promising strategies to stabilize gelatin or collagen include glutaraldehyde-based chemical cross-linking or dehydrothermal treatment at different temperatures (120-180 °C). However, these procedures require 24-48 h for complete cross-linking to occur. The present study aims to evaluate the role of wheat gluten on enhancing thermal cross-linking of silica-nanohydroxyapatite (nanoHA)-gelatin composite scaffolds within a shorter period (2 h). Changes in properties were evaluated by varying the ratio of gelatin and gluten in silica-nanoHA matrix (60 wt% ceramic: 40 wt% polymer). The results showed that the scaffolds cross-linked at 170 °C were stable in phosphate-buffered saline for 21 days. It was crystalline and porous in nature. However, the scaffolds with high weight percentage of wheat gluten were brittle, while those with low gluten degraded fast in vitro. The mesenchymal stem cells could adhere, proliferate and differentiate into osteogenic lineage on wheat gluten-containing scaffolds for 21 days (mainly medium concentration). The scaffold also supported new bone formation in critical-sized rat calvarial defect, showing its osteoconductive and osteointegrative nature. In short, this study showed the potential of wheat glute...Continue Reading

References

May 15, 2002·Biomacromolecules·Marie-Hélène MorelStéphane Guilbert
Jun 13, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hyun Goo KangYoung Moo Lee
Sep 30, 2006·Food Microbiology·Herbert Wieser
Oct 31, 2007·Journal of Materials Science. Materials in Medicine·Narendra Reddy, Yiqi Yang
Apr 24, 2008·Journal of Biomedical Materials Research. Part a·Matthew G HaughFergal J O'Brien
Oct 15, 2008·Journal of Materials Science. Materials in Medicine·Manitha B NairAnnie John
Dec 17, 2009·Journal of Materials Science. Materials in Medicine·S BertoldiM C Tanzi
Jul 3, 2010·Tissue Engineering. Part C, Methods·Jason W Drexler, Heather M Powell
Jul 20, 2010·International Journal of Biological Macromolecules·Juthamas RatanavarapornSiriporn Damrongsakkul
Aug 13, 2015·Journal of Biomedical Materials Research. Part a·Marta MadaghieleAlessandro Sannino
Mar 26, 2016·International Journal of Biological Macromolecules·S DeepthiR Jayakumar
Oct 28, 2016·Journal of Food Science and Technology·Vandana Dhaka, B S Khatkar
Sep 27, 2018·International Journal of Biomaterials·Pawan Kumar
Aug 7, 2019·Materials·Chiara Emma CampiglioLorenza Draghi
Sep 11, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Manju VManitha B Nair
Mar 25, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Shruthy KuttappanManitha B Nair
Feb 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xingxing FangJun Ouyang
Aug 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·F S L Bobbert, A A Zadpoor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Nutrition
W L BanksR W Wannemacher
Biochimica Et Biophysica Acta
R H DE DEKENJ M WIAME
Biochimica Et Biophysica Acta
R H DE DEKEN, A MORTIER
Advances in Genetics
Peter ShewryDomenico Lafiandra
© 2021 Meta ULC. All rights reserved