PMID: 8603263Mar 1, 1996Paper

Effect of whole-body hyperthermia on AIDS patients with Kaposi's sarcoma: a pilot study

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
C R SteinhartM B Yatvin

Abstract

The safety and possible efficacy of extracorporeal whole-body hyperthermia (WBHT) were evaluated in the first FDA-approved feasibility study of WBHT in persons with AIDS. Six gay men, aged 20-50 years, CDC class C-3, underwent 1 h of WBHT at either 40 degrees C or 42 degrees C, employing a system that minimizes the physiological and biochemical changes that occur during WBHT. All subjects had Kaposi's sarcoma (KS), were free of opportunistic infections, and had significant elevations of plasma HIV RNA. During the treatment, there were no adverse side effects and all subjects tolerated WBHT without problems. KS lesions partially regressed immediately following WBHT in all subjects but returned to pretreatment status in five of six patients at 1 week. In subjects treated at 40 degrees C, CD4 counts decreased during the 8-week follow-up period; they remained unchanged, however, following 42 degrees C WBHT. Viral load remained unchanged following WBHT in subjects treated at 40 degrees C. Treatment at 42 degrees C resulted in an immediate reduction in HIV RNA that was not sustained at 1 week post-WBHT. We conclude that WBHT is safe in subjects with advanced HIV disease and that it may have a role in treating HIV infection. A larger ...Continue Reading

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Citations

Jul 25, 2003·Experimental Cell Research·Natalia A Ignatenko, Eugene W Gerner
Jun 3, 2004·The Annals of Thoracic Surgery·Joseph B ZwischenbergerLee C Woodson
May 15, 2010·Journal of the American Academy of Dermatology·Christy Badgwell DohertyTheodore Rosen

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