PMID: 6978405Nov 1, 1981Paper

Effect of whole-body hyperthermia on delayed cutaneous hypersensitivity to oxazolone in mice

Journal of Clinical & Laboratory Immunology
W RoszkowskiJ Jeljaszewicz

Abstract

A murine model of delayed cutaneous hypersensitivity has been used to study an effect of microwave whole-body hyperthermia on the immune system. Marked suppression of immune responsiveness was observed in mice exposed to repeated sessions of hyperthermia. Cell proliferation in regional lymph nodes of mice sensitized with oxazolone was significantly impaired as measured by uptake of 125I-iododeoxyuridine (125IUdR). The proportion of theta-positive cells and the total number of lymph node lymphocytes remained unchanged. Inhibition of proliferation of lymph node lymphocytes in vivo was accompanied by a decrease in mitogen-induced stimulation of lymphocytes in vitro. In particular the phytohaemagglutinin (PHA) response of T cells was affected by hyperthermia. It is concluded that whole-body hyperthermia can be a potent immunosuppressive factor.

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Transactions of the Royal Society of Tropical Medicine and Hygiene
Y H ThongD E O'Keefe
Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
W HryniewiczJ Jeljaszewicz
© 2021 Meta ULC. All rights reserved