Effect of whole-body vibration on bone properties in aging mice

Bone
Karl H WengerJack C Yu

Abstract

Recent studies suggest that whole-body vibration (WBV) can improve measures of bone health for certain clinical conditions and ages. In the elderly, there also is particular interest in assessing the ability of physical interventions such as WBV to improve coordination, strength, and movement speed, which help prevent falls and fractures and maintain ambulation for independent living. The current study evaluated the efficacy of WBV in an aging mouse model. Two levels of vibration--0.5 and 1.5g--were applied at 32Hz to CB57BL/6 male mice (n=9 each) beginning at age 18 months and continuing for 12 weeks, 30 min/day, in a novel pivoting vibration device. Previous reports indicate that bone parameters in these mice begin to decrease substantially at 18 months, equivalent to mid-fifties for humans. Micro-computed tomography (micro-CT) and biomechanical assessments were made in the femur, radius, and lumbar vertebra to determine the effect of these WBV magnitudes and durations in the aging model. Sera also were collected for analysis of bone formation and breakdown markers. Mineralizing surface and cell counts were determined histologically. Bone volume in four regions of the femur did not change significantly, but there was a consis...Continue Reading

References

Apr 1, 1993·American Journal of Industrial Medicine·H Seidel
Feb 15, 2001·Occupational and Environmental Medicine·M BovenziM J Griffin
Aug 10, 2001·Drug Discovery Today·C T. RubinY -X. Qin
Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C RubinS Judex
May 8, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Saila TorvinenIlkka Vuori
Jun 5, 2003·Medicine and Science in Sports and Exercise·Christophe DelecluseSabine Verschueren
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Clinton RubinKenneth McLeod
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sabine M P VerschuerenSteven Boonen
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kate WardZulf Mughal
May 27, 2004·Journal of the American Geriatrics Society·Machteld RoelantsSabine M Verschueren
Oct 27, 2004·American Journal of Physical Medicine & Rehabilitation·Ilse J W van NesJacques Duysens
Dec 3, 2004·Journal of Strength and Conditioning Research·Darryl J CochraneMichael J Hooker
Dec 15, 2004·Journal of Cellular Biochemistry·Stefan JudexClinton T Rubin
Feb 12, 2005·Archives of Physical Medicine and Rehabilitation·Olivier BruyereJean-Yves Reginster
Jun 24, 2005·Clinical Physiology and Functional Imaging·Eiji YamadaSusumu Itoh
Aug 17, 2005·Industrial Health·Chris M Nelson, Paul F Brereton
Sep 15, 2005·International Journal of Sports Medicine·C DelecluseS Verschueren
Dec 6, 2005·Clinical Rehabilitation·Othmar SchuhfriedTatjana Paternostro-Sluga
Jan 6, 2006·Research in Sports Medicine·Stephan TurbanskiPetra Duisberg
Feb 17, 2006·European Journal of Applied Physiology·Thue KvorningKlavs Madsen
Mar 1, 2006·Journal of Strength and Conditioning Research·Roland van den Tillaar
May 6, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rommel G BacabacJenneke Klein-Nulend
May 12, 2006·Journal of Strength and Conditioning Research·Prue CormieJeffrey M McBride
Jun 21, 2006·Annals of Biomedical Engineering·Blaine A Christiansen, Matthew J Silva
Aug 31, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Vicente GilsanzClinton Rubin
Nov 23, 2006·American Journal of Physical Medicine & Rehabilitation·Federica FagnaniValter Di Salvo
Jan 12, 2007·Research in Sports Medicine·Christian T HaasDietmar Schmidtbleicher
Apr 7, 2007·Medicine and Science in Sports and Exercise·Marco CardinaleValentina Quaresima
Jul 3, 2007·Archives of Physical Medicine and Rehabilitation·Wing-Hoi CheungKwok-Sui Leung
Oct 3, 2007·Medicine and Science in Sports and Exercise·Andrew F J AbercrombyWilliam H Paloski
Feb 9, 2008·Journal of Applied Physiology·Liqin XieStefan Judex
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Juha KiiskiHarri Sievänen
Aug 22, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yen Kim LuuClinton T Rubin
Oct 17, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kwok Sui LeungNing Tang
Aug 7, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michelle A LynchMatthew J Silva
Jun 29, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Everett B LohmanSherwine Paul

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Citations

Nov 3, 2011·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·BaiLing ChenDengHui Xie
Apr 15, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Esther WehrleAnita Ignatius
Dec 24, 2014·Annals of Biomedical Engineering·Karyne N RabeyDaniel Schmitt
Mar 7, 2017·PloS One·Ryohei UchidaHideki Yoshikawa
Mar 23, 2017·Endocrinology·Meghan E McGee-LawrenceAlexis M Stranahan
Mar 1, 2019·Nature Reviews. Endocrinology·Gabriel M PagnottiClinton T Rubin
Feb 22, 2012·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Renshi MaXizheng Zhang
Nov 17, 2020·Frontiers in Bioengineering and Biotechnology·Lena SteppeMelanie Haffner-Luntzer

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