Effect of Wuling Powder on rats with renal hypertension

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Yu-Ping HanQi-De Liu

Abstract

To observe the therapeutic effect of Wuling Powder extract on rats with renal hypertension and to evaluate the influence of it on the volume of urine and the concentrations of Na(+), K(+), Cl(-). Reformed Gold-blatt hypertension rat model (G-2K1C) was established. The rats were divided into 6 groups as follows: sham-operation group; model group, Wuling Powder high dosage group (80 g/kg), Wuling Powder middle dosage group (40 g/kg), Wuling Powder low dosage group (20 g/kg), and hydrochlorothiazide (HCT) group (25 mg/kg). Urine volume of the rats was measured during the experiment. Tail arterial pressure and [Na(+)], [K(+)], [Cl(-)] in serum of the rats were detected after 30 days of treatment. The blood pressure of the G-2K1C rats was decreased in the three Wuling Powder groups (P<0.05 or P<0.01), but higher than that of the false-operation group (P<0.01), and there was no difference between each of the Wuling Powder groups and the HCT group (P>0.05). Diuretic effect of the three dosages of Wuling Powder was weaker than that of the HCT (P<0.05 or P<0.01). The effects of the three dosages of Wuling Powder and HCT on [Na(+)] and [Cl(-)] in the serum were not obviously different (P>0.05), but [K(+)] of the HCT group was significant...Continue Reading

Citations

Jul 24, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Xingjiang XiongJie Wang
Mar 25, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Jie WangWei Liu
Jan 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Kiwan KangInsoo Jang

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