PMID: 8953505Oct 1, 1996Paper

Effect of YM934, a novel potassium-channel opener, in various experimental asthma models in guinea-pigs

The Journal of Pharmacy and Pharmacology
J IshikawaM Asano

Abstract

YM934 is a novel synthetic potassium-channel opener. We have investigated its anti-asthma effect after intravenous (i.v.) and oral (p.o.) administration in various experimental asthma models in the guinea-pig, and compared the results with those for lemakalim, theophylline and salbutamol. In an ovalbumin-active sensitization anaphylaxis asthma model, YM934, lemakalim, theophylline and salbutamol dose-dependently prolonged the time before the occurrence of asthma attacks and reduced the mortality rate. The respective ED50 values (dose required to prolong by 50% the time before the occurrence of attacks) of the anti-asthma effects of YM934, lemakalim, theophylline and salbutamol were 6, 340, 30000, and 45 micrograms kg-1 (i.v.); the efficacy ratios were YM934 (1) > salbutamol (1/9) > lemakalim (1/57) > > theophylline (1/5000). YM934 also prolonged the period before the occurrence of attacks in the anti-BSA (bovine serum albumin) serum-passive sensitization anaphylaxis, histamine-induced and methacho-line-induced asthma models, with respective ED50 values for these models of 15, 22 and 20 micrograms kg-1 (i.v.). Among these models a reduction in mortality rate was seen in the histamine- and methacholine-induced asthma models. Afte...Continue Reading

References

Apr 1, 1992·British Journal of Pharmacology·D M GoodT C Hamilton
Sep 1, 1991·British Journal of Pharmacology·J F BurkaA J Watt
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Citations

Feb 7, 2001·Biochemical Pharmacology·W S Wong, D S Koh
Feb 5, 2002·Expert Opinion on Pharmacotherapy·A JahangirW K Shen

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