Effect of yohimbine on urethane-induced hyperglycemia in rats

Japanese Journal of Pharmacology
K AisakaT Ishihara

Abstract

Urethane is a widely used anesthetic and yohimbine is a well-known alpha 2-adrenergic antagonist. In fasted Wistar rats urethane at an anesthetic dose (1.25 g/kg, i.p.) caused an increase in plasma glucose, while pentobarbital at an anesthetic dose (40 mg/kg, i.p.) did not. Urethane caused no change in plasma glucose in adrenalectomized rats. The hyperglycemic effect of urethane was not inhibited by pretreatment with propranolol (1 mg/kg, p.o.) or prazosin (10 mg/kg, p.o.), but was reduced by pretreatment with phentolamine (10 mg/kg, p.o.) or yohimbine (10 mg/kg, p.o.). Urethane caused an elevation of plasma adrenaline, and yohimbine reduced the elevation. In addition, the pretreatment of yohimbine potentiated the urethane-induced increase in plasma insulin. These results indicate that yohimbine may inhibit the urethane-induced hyperglycemia that is mediated by the central and peripheral alpha 2-adrenergic systems.

Citations

May 18, 2010·Neuroscience Letters·Dmitry V ZaretskyJoseph A DiMicco
Aug 22, 2006·International Journal of Pharmaceutics·Seiji TokumotoKenji Sugibayashi
Apr 18, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T Dylan OlverJ Kevin Shoemaker

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