Effect of Zinc and Melatonin on Oxidative Stress and Serum Inhibin-B Levels in a Rat Testicular Torsion-Detorsion Model

Biochemical Genetics
Atilla SemerciozMustafa Cihat Avunduk

Abstract

The present study was aimed to examine the effects of 3-week zinc and melatonin administration on testicular tissue injury and serum Inhibin-B levels caused by unilateral testicular torsion-detorsion in rats. The study was performed on 60 Wistar Albino-type adult male rats. The animals were allocated to 6 groups in equal numbers. 1. Control; 2. Sham; 3. Ischemia-reperfusion; 4. Zinc + ischemia-reperfusion; 5. Melatonin + ischemia-reperfusion; 6. Zinc + melatonin + ischemia-reperfusion. Zinc and melatonin were administered before ischemia-reperfusion at doses of 5 and 3 mg/kg respectively, by intraperitoneal route for a period of 3 weeks. Testicular torsion-detorsion procedures consisted of ischemia for 1 h and then reperfusion for another hour of the left testis. Blood and testicular tissue samples were collected to analyze erythrocyte and tissue GSH and plasma and tissue MDA, Inhibin-B levels. The highest erythrocyte and testis GSH values were found in zinc, melatonin, and zinc + melatonin groups (p < 0.001). Torsion-detorsion group has significantly lower erythrocyte GSH levels and higher plasma MDA values (p < 0.001). Serum inhibin-B and spermatogenic activity levels in the torsion-detorsion group were also significantly low...Continue Reading

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Citations

Jul 31, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Zeynep Banu DoğanlarOğuzhan Doğanlar
Dec 13, 2019·Biological Trace Element Research·Ghaidafeh Akbari
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Nov 18, 2020·Canadian Journal of Physiology and Pharmacology·Sama S KhalilNanees F El-Malkey
Aug 10, 2021·Journal of Pediatric Urology·Christina HoDaniel P Casella
Nov 7, 2021·Biological Trace Element Research·Maha LokmanNabil A El-Yamany

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Methods Mentioned

BETA
MDA
ELISA
biopsy

Software Mentioned

SPSS

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