Abstract
Poor child growth increases risks of mortality and morbidity. Micronutrient supplements have the potential to improve child growth. We assessed the effect of daily zinc, multivitamin (vitamins C, E, and B-complex), and zinc and multivitamin (Zn+MV) supplementation on growth in infants in Tanzania. In this randomized, 2 × 2 factorial, double-blind trial, 2400 infants were randomly assigned to receive zinc, multivitamins, Zn+MVs, or a placebo at 6 wk of age and were followed up for 18 mo with monthly growth measurements. Mixed-effects models with restricted cubic splines for the mean change in anthropometric z scores were fit for each group. Likelihood ratio tests were used to compare the effect of supplements on growth trajectories. Cox proportional hazards models were used to compare incidences of stunting, wasting, and underweight. Children in all groups experienced growth faltering. At 19 mo of age, prevalences of stunting, wasting, and underweight were 19.8%, 6.0%, and 10.8%, respectively. Changes in weight-for-age z scores (WAZs) and weight-for-height z scores (WHZs) were significantly different across the 4 groups (P < 0.001 for both). The mean ± SE decline in the WAZ from baseline to the end of follow-up in the Zn+MV grou...Continue Reading
References
Jun 1, 1991·Biological Trace Element Research·R A Wapnir, C Balkman
May 1, 1989·Statistics in Medicine·S Durrleman, R Simon
May 31, 2002·Nutrition Reviews·Usha Ramakrishnan
May 31, 2002·The American Journal of Clinical Nutrition·Kenneth H BrownLindsay H Allen
Sep 27, 2002·The American Journal of Clinical Nutrition·Susilowati HermanSteven A Abrams
Jul 10, 2003·BMC Pediatrics·Emily OkenMatthew W Gillman
Aug 27, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA) Study Group
Mar 1, 2005·The Journal of Nutrition·Cornelius M SmutsUNKNOWN International Research on Infant Supplementation (IRIS) Study Group
Mar 1, 2005·The Journal of Nutrition·Juliawati UntoroRainer Gross
Mar 1, 2005·The Journal of Nutrition·Guillermo López de RomañaRainer Gross
Mar 1, 2005·The Journal of Nutrition·Le Thi Hop, Jacques Berger
Apr 9, 2005·The American Journal of Clinical Nutrition·Eduardo VillamorWafaie W Fawzi
Jan 31, 2006·The Proceedings of the Nutrition Society·Rosalind S Gibson
Aug 23, 2006·The British Journal of Nutrition·Maria Neira, Mercedes de Onis
Mar 22, 2007·The Journal of Nutrition·Purnima MenonLesly Michaud
Apr 6, 2007·The New England Journal of Medicine·Wafaie W FawziDonna Spiegelman
Jan 22, 2008·Lancet·Cesar G VictoraUNKNOWN Maternal and Child Undernutrition Study Group
Jan 22, 2008·Lancet·Zulfiqar A BhuttaUNKNOWN Maternal and Child Undernutrition Study Group
Dec 6, 2008·The American Journal of Clinical Nutrition·Usha RamakrishnanReynaldo Martorell
Mar 27, 2009·The Journal of Nutrition·Lindsay H AllenDeanna K Olney
May 29, 2009·Food and Nutrition Bulletin·Kenneth H BrownSonja Y Hess
Nov 10, 2009·Statistics in Medicine·X Basagaña, D Spiegelman
Mar 20, 2010·BMC Public Health·Meera K ChhaganMichael L Bennish
Apr 29, 2011·BMC Public Health·Aamer Imdad, Zulfiqar A Bhutta
Oct 1, 2011·The Journal of Nutrition·Usha RamakrishnanLindsay H Allen
Dec 14, 2011·The Journal of Nutrition·Parul Christian, James M Tielsch
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Marzia Lazzerini, Luca Ronfani
Mar 22, 2013·The Journal of Nutrition·Roland KupkaChristopher Duggan
Apr 23, 2013·Lancet·Sajid SoofiZulfiqar A Bhutta
Jun 5, 2013·PloS One·Ibironke OlofinUNKNOWN Nutrition Impact Model Study (anthropometry cohort pooling)
Jun 12, 2013·Lancet·Robert E BlackUNKNOWN Maternal and Child Nutrition Study Group
Sep 10, 2014·Paediatrics and International Child Health·Nancy F KrebsK Michael Hambidge
Jul 24, 2015·The Journal of Nutrition·Christine M McDonaldChristopher P Duggan
Aug 8, 2015·The American Journal of Clinical Nutrition·David L Streiner
Citations
May 18, 2016·Maternal & Child Nutrition·Lindsey M LocksChristopher P Duggan
Nov 11, 2016·The Journal of Pediatrics·Lindsey M LocksChristopher P Duggan
Jun 28, 2016·Journal of Pediatric Gastroenterology and Nutrition·Kerri B GosselinChristopher Duggan
Apr 9, 2020·The Cochrane Database of Systematic Reviews·Zohra S LassiZulfiqar A Bhutta
Oct 6, 2019·BMJ Open·Ayesha SaniaWafaie Fawzi
Jul 10, 2018·BMJ Open·Mark Daniel DeBoerEstomih Mduma
Jun 22, 2019·BMC Gastroenterology·Xiaoyang ShengJingqiu Ma
Jul 28, 2019·JAMA Network Open·Jay J H ParkZulfiqar A Bhutta
Aug 29, 2018·Nutrients·Sana SyedChristopher P Duggan
Apr 3, 2019·International Journal of Environmental Research and Public Health·Lauren C ManzioneBenjamin T Crookston
Oct 21, 2020·Gates Open Research·Jay J H ParkEdward J Mills
Dec 12, 2020·Wellcome Open Research·Isabella StelleSophie E Moore
May 14, 2017·The Journal of Pediatrics·Lindsey M LocksChristopher P Duggan
Jun 22, 2021·International Journal of Epidemiology·Dongqing WangWafaie W Fawzi