Effect of zinc and multivitamin supplementation on the growth of Tanzanian children aged 6-84 wk: a randomized, placebo-controlled, double-blind trial

The American Journal of Clinical Nutrition
Lindsey M LocksChristopher Duggan

Abstract

Poor child growth increases risks of mortality and morbidity. Micronutrient supplements have the potential to improve child growth. We assessed the effect of daily zinc, multivitamin (vitamins C, E, and B-complex), and zinc and multivitamin (Zn+MV) supplementation on growth in infants in Tanzania. In this randomized, 2 × 2 factorial, double-blind trial, 2400 infants were randomly assigned to receive zinc, multivitamins, Zn+MVs, or a placebo at 6 wk of age and were followed up for 18 mo with monthly growth measurements. Mixed-effects models with restricted cubic splines for the mean change in anthropometric z scores were fit for each group. Likelihood ratio tests were used to compare the effect of supplements on growth trajectories. Cox proportional hazards models were used to compare incidences of stunting, wasting, and underweight. Children in all groups experienced growth faltering. At 19 mo of age, prevalences of stunting, wasting, and underweight were 19.8%, 6.0%, and 10.8%, respectively. Changes in weight-for-age z scores (WAZs) and weight-for-height z scores (WHZs) were significantly different across the 4 groups (P < 0.001 for both). The mean ± SE decline in the WAZ from baseline to the end of follow-up in the Zn+MV grou...Continue Reading

Associated Clinical Trials

References

Jun 1, 1991·Biological Trace Element Research·R A Wapnir, C Balkman
May 1, 1989·Statistics in Medicine·S Durrleman, R Simon
May 31, 2002·Nutrition Reviews·Usha Ramakrishnan
Sep 27, 2002·The American Journal of Clinical Nutrition·Susilowati HermanSteven A Abrams
Aug 27, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA) Study Group
Mar 1, 2005·The Journal of Nutrition·Cornelius M SmutsUNKNOWN International Research on Infant Supplementation (IRIS) Study Group
Apr 9, 2005·The American Journal of Clinical Nutrition·Eduardo VillamorWafaie W Fawzi
Jan 31, 2006·The Proceedings of the Nutrition Society·Rosalind S Gibson
Aug 23, 2006·The British Journal of Nutrition·Maria Neira, Mercedes de Onis
Apr 6, 2007·The New England Journal of Medicine·Wafaie W FawziDonna Spiegelman
Jan 22, 2008·Lancet·Cesar G VictoraUNKNOWN Maternal and Child Undernutrition Study Group
Jan 22, 2008·Lancet·Zulfiqar A BhuttaUNKNOWN Maternal and Child Undernutrition Study Group
Dec 6, 2008·The American Journal of Clinical Nutrition·Usha RamakrishnanReynaldo Martorell
May 29, 2009·Food and Nutrition Bulletin·Kenneth H BrownSonja Y Hess
Oct 1, 2011·The Journal of Nutrition·Usha RamakrishnanLindsay H Allen
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Marzia Lazzerini, Luca Ronfani
Mar 22, 2013·The Journal of Nutrition·Roland KupkaChristopher Duggan
Jun 5, 2013·PloS One·Ibironke OlofinUNKNOWN Nutrition Impact Model Study (anthropometry cohort pooling)
Jun 12, 2013·Lancet·Robert E BlackUNKNOWN Maternal and Child Nutrition Study Group
Sep 10, 2014·Paediatrics and International Child Health·Nancy F KrebsK Michael Hambidge

❮ Previous
Next ❯

Citations

Jun 28, 2016·Journal of Pediatric Gastroenterology and Nutrition·Kerri B GosselinChristopher Duggan
Apr 9, 2020·The Cochrane Database of Systematic Reviews·Zohra S LassiZulfiqar A Bhutta
Apr 3, 2019·International Journal of Environmental Research and Public Health·Lauren C ManzioneBenjamin T Crookston

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.