PMID: 3766452Nov 1, 1986Paper

Effect of zinc deficiency on mucosal hyperplasia following 70% bowel resection

The American Journal of Clinical Nutrition
J A VanderhoofC J Grandjean

Abstract

We evaluated the effect of zinc deficiency on the development of mucosal hyperplasia in male Sprague-Dawley rats following 70% small-bowel resection: 20 underwent 70% jejunoileal resection, another 20 were sham operated. Half of each group were made zinc deficient by force-feeding technique. Operations were then performed, and feedings were continued for another 9 days. While mucosal weight did not differ between zinc-deficient and zinc-replete animals, whether or not they underwent resection, mucosal protein and DNA levels were decreased in both resected and sham-operated, zinc-deficient animals. Functional indices were also affected. Maltase activities were decreased in zinc-deficient animals in the midileum. Mucosal zinc-dependent enzymes, alkaline phosphatase and leucine aminopeptidase, were likewise depressed in zinc-deficient animals. Findings suggest that zinc deficiency in short-bowel syndrome will likely impair mucosal hyperplasia.

Citations

Jan 16, 2007·Journal of Animal Physiology and Animal Nutrition·D CarlsonH D Poulsen
Dec 1, 2017·JPEN. Journal of Parenteral and Enteral Nutrition·Shweta S NamjoshiLaura J Wozniak
Jan 1, 1989·European Journal of Pediatrics·M J Lentze
Apr 27, 2002·The American Journal of Clinical Nutrition·Christopher DugganW Allan Walker
Mar 11, 2003·Annual Review of Nutrition·Thomas R ZieglerDean P Jones
Jul 19, 2008·Journal of Nutritional Science and Vitaminology·Yoko HorikawaNanaya Tamaki
Oct 19, 2010·The Journal of Veterinary Medical Science·Keiko HamaguchiSoichi Imai
Sep 23, 2014·The Journal of Pediatrics·Kerri B Gosselin, Christopher Duggan

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