Effect of zinc depletion/repletion on intestinal iron absorption and iron status in rats.

The Journal of Nutritional Biochemistry
Palsa KondaiahRaghu Pullakhandam

Abstract

Iron and zinc deficiencies likely coexist in general population. We have previously demonstrated that zinc treatment induces while zinc deficiency inhibits iron absorption in intestinal cell culture models, but this needs to be tested in vivo. In the present study we assessed intestinal iron absorption, iron status (haemoglobin), red blood cell number, plasma ferritin, transferrin receptor, hepcidin) and tissue iron levels in zinc depleted, replete and pair fed control rats. Zinc depletion led to reduction in body weight, tissue zinc levels, intestinal iron absorption, protein and mRNA expression of iron transporters, the divalent metal ion transporter-1, hephaestin and ferroportin, but elevated the intestinal and liver tissue iron levels compared with the pair fed control rats. Zinc repletion led to a significant weight gain compared to zinc deficient rats and normalized the iron absorption, iron transporter expression, tissue iron levels to that of pair fed control rats. Surprisingly, haemoglobin levels and red blood cell number reduced significantly in zinc repleted rats, which could be due to rapid weight gain. Together, these results indicate that whole body zinc status has profound influence on growth, intestinal absorpti...Continue Reading

References

Apr 1, 1967·The Journal of Clinical Investigation·A S PrasadH P Horwitz
Dec 1, 1970·The British Journal of Nutrition·J K Chesters, J Quarterman
Dec 1, 1970·The British Journal of Nutrition·R B Williams, C F Mills
Mar 1, 1984·Physiology & Behavior·M B EssataraC J McClain
Dec 1, 1982·British Journal of Obstetrics and Gynaecology·D J TaylorT Lind
Jul 1, 1995·The Proceedings of the Nutrition Society·S J Fairweather-Tait
Aug 13, 1998·The American Journal of Clinical Nutrition·P Whittaker
May 10, 2000·The Journal of Nutrition·J C KingL R Woodhouse
May 10, 2000·The Journal of Nutrition·B Lönnerdal
Nov 8, 2002·The Journal of Nutrition·Louis E King, Pamela J Fraker
Jan 28, 2003·Blood Cells, Molecules & Diseases·Gregory J AndersonChristopher D Vulpe
Aug 31, 2007·World Journal of Gastroenterology : WJG·Paul Sharp, Surjit-Kaila Srai
Oct 30, 2007·World Journal of Gastroenterology : WJG·Sreedhar Bodiga, Madhavan Nair Krishnapillai
Feb 12, 2010·The American Journal of Clinical Nutrition·Conrad R ColeThomas R Ziegler
Jul 6, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sukru GulecJames F Collins
Oct 7, 2015·Cell Metabolism·Hal DrakesmithTomas Ganz
Mar 11, 2016·The Journal of Nutrition·Janet C KingDaniel J Raiten
Sep 21, 2018·International Journal of Molecular Sciences·Yen-Hua ChenSen-Shyong Jeng
May 17, 2019·The Biochemical Journal·Palsa KondaiahRaghu Pullakhandam
Jan 25, 2020·Biochemical and Biophysical Research Communications·Palsa KondaiahRaghu Pullakhandam

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