Effect of Zinc Supplementation on GH, IGF1, IGFBP3, OCN, and ALP in Non-Zinc-Deficient Children

Journal of the American College of Nutrition
Érika Dantas de Medeiros RochaJosé Brandão-Neto

Abstract

Because most publications on growth and development deal with children with zinc deficiency, we decided to study the effects of this micronutrient on the secretion of growth hormone (GH), insulin-like growth factor 1 (IGF1), insulin-like growth factor binding protein 3 (IGFBP3), osteocalcin (OCN), and alkaline phosphatase (ALP) in healthy and eutrophic children. This study is original because the methodology was unique. Forty schoolchildren participated in the study, 17 females and 23 males, aged 8 and 9 years. The study was carried out during a 3-month period. It was characterized as a triple-blind randomized controlled trial. The children were divided in a control group (20 schoolchildren using 10% sorbitol) and experimental group (20 schoolchildren using zinc). All were submitted to oral zinc supplementation (10 mg Zn/day) and venous zinc administration (0.06537 mg Zn/kg of body weight). Blood samples were collected at 0, 60, 120, 180, and 210 min. All schoolchildren were also submitted to anthropometric, clinical, and dietetic assessments as well as biochemistry analyses. Oral zinc supplementation in the experimental group (1) stimulated an increase in the consumption of protein and fat (p = 0.0007, p < 0.0001, p < 0.0001, ...Continue Reading

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Citations

Apr 1, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Hsun-Chin ChaoWan-Ling Huang
Dec 7, 2017·Nutrition Research and Practice·Seul-Gi ParkJung-Eun Yim
Feb 5, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Ibrahim ElmadfaVerena Hasenegger
May 28, 2020·Journal of Clinical Medicine·Hiroki NishikawaHiroko Iijima
Aug 18, 2020·Molecular and Cellular Endocrinology·Jaanis Lodjak, Simon Verhulst
Jul 3, 2021·Cells·Marina CaputoFlavia Prodam
Jul 27, 2021·Domestic Animal Endocrinology·M Sadegzadeh-SadatS Asri-Rezaei

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Software Mentioned

NutWin
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