PMID: 1203701Dec 13, 1975Paper

Effect on adrenal function of topically applied clobetasol propionate (Dermovate)

British Medical Journal
C F AllenbyC G Sparkes

Abstract

Thirty-nine patients (15 outpatients and 24 inpatients) with a variety of skin diseases affecting variable areas of the body surface were treated with clobetasol propionate ointment (Dermovate). Before and after treatment the adrenal response to an intramuscular injection of tetracosactrin was rested and additional 9 am plasma cortisol levels were measured at intervals during treatment. A satisfactory initial therapeutic response was achieved in almost all cases during the trial period. When more than 50 g of ointment a week was used a significant number of patients developed adrenal suppression. WHen less than 50 g per week was used any suppression tended to be transtion. These cysts may be the cause of this condition, producing abnormal amounts of ovarian steroids which modify the pituitary response. Futher studies are needed, however, to determine this possibility.

References

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Citations

Jan 1, 1980·Archives of Dermatological Research·R Wrench
Apr 13, 1991·Lancet·C C Long, R Marks
Jul 26, 1986·Lancet·G M FairrisB A Leatherdale
Nov 3, 2009·Indian Journal of Psychiatry·Srinivasa Sastry Malladi
May 27, 2014·Indian Dermatology Online Journal·Alberto de la Fuente-GarcíaFernando Lavalle-González
Oct 7, 2014·Indian Journal of Dermatology·Sandipan DharDeepak Parikh
Nov 22, 2014·Dermatologic Clinics·M Alan Menter, Christopher E M Griffiths
Feb 1, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Charles N J McGheeHelen Danesh-Meyer
May 15, 2007·The American Journal of the Medical Sciences·Ramazan GenKerem Sezer
Mar 1, 1995·Seminars in Dermatology·B R Krafchik
May 28, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·I GardinalC Paul
Feb 18, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·M A Gonzalez-Moles, C Scully
Jan 1, 1986·Clinics in Dermatology·R J Coskey
Jan 17, 2007·Journal of the American Academy of Dermatology·Jennifer KwinterElena Pope
Oct 30, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Clemens PainsiPeter Wolf
May 22, 2001·The British Journal of Dermatology·F M KeaneA W du Vivier
Dec 15, 1976·Harefuah·M Schewach-Millet
Jan 1, 1985·Clinical and Experimental Dermatology·S M HardingM J Busse
Mar 1, 1976·The British Journal of Dermatology·C G Sparkes
Sep 1, 1985·International Journal of Dermatology·B JegasothyM Porter
Apr 1, 1983·The Australasian Journal of Dermatology·G O Fischer
Dec 1, 1978·The Australasian Journal of Dermatology·P C Bartley
Dec 1, 1978·International Journal of Dermatology·A Kansky
May 1, 1996·Pediatric Dermatology·D J HepburnW L Weston
Apr 7, 2019·Expert Review of Clinical Pharmacology·Kabir SardanaAastha Gupta
Apr 7, 2015·The Journal of Clinical Endocrinology and Metabolism·Leonie H A BroersenOlaf M Dekkers
Jun 20, 2012·The Medical Journal of Australia·Rebecca F GoldsteinCarolyn A Allan
Jan 1, 1977·The Journal of International Medical Research·V Voigtländer
Jun 1, 1976·Clinical and Experimental Dermatology·A P Warin, J A Carruthers
Mar 10, 1999·Journal of Cutaneous Medicine and Surgery·B R Krafchik
May 16, 2020·Clinical and Experimental Dermatology·S A MirzaM D P Davis
Jul 1, 1987·Journal of the Royal Society of Medicine·E M OhmanT J McKenna
Dec 31, 2020·The Journal of Dermatology·Kyohei Miyano, Yuichiro Tsunemi
Jan 24, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zifu ZhongNiek N Sanders

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