The forced expiratory volume in one second (F.E.V.(1)) was measured in healthy and asthmatic volunteers and the inhalation of prostaglandin E(1) (PGE(1)) was compared with that of isoprenaline, using metered aerosols.In healthy volunteers PGE(1), either as the free acid or the neutral triethanolamine salt, did not affect the F.E.V.(1); the free acid was irritant to the upper respiratory tract. In five out of six asthmatic volunteers with reversible airways obstruction, inhalation of 55 mug of PGE(1) (triethanolamine salt) produced an increase in F.E.V.(1) comparable in both degree and duration to that produced by an inhalation of 550 mug. of isoprenaline sulphate.Though the triethanolamine salt was well tolerated in most of the asthmatic subjects studied, in one asthmatic subject this preparation caused coughing and there was a progressive reduction in the F.E.V.(1) associated with bronchospasm.
Aerosol administration of prostaglandins E 1 and E 2 and isoproterenol: studies on the cardiovascular system
Circulatory and pulmonary airway responses to different mixtures of prostaglandins E2 and F2 alpha in dogs
2-decarboxy-2-hydroxymethyl prostaglandin E1 (TR4161), a prostaglandin bronchodilator of low tracheobronchial irritancy
The effects of oral propranolol and indomethacin on the response to inhaled PGE2 in normal human subjects
Interactions between response to inhaled prostaglandin E2 and chronic beta-adrenergic agonist treatment
Adenosine A(1) and prostaglandin E receptor 3 receptors mediate global airway contraction after local epithelial injury
Alterations in cyclic AMP metabolism in human bronchial asthma. II. Leukocyte and lymphocyte responses to prostaglandins
Hyperresponsiveness to inhaled but not intravenous methacholine during acute respiratory syncytial virus infection in mice
Spontaneous activity in the trachea of dogs treated with indomethacin: an experimental model for aspirin-related asthma
Morphine-like drugs inhibit the stimulation of E prostaglandins of cyclic AMP formation by rat brain homogenate
A microphysiological model of the bronchial airways reveals the interplay of mechanical and biochemical signals in bronchospasm
Characterization of prostanoid relaxant/inhibitory receptors (psi) using a highly selective agonist, TR4979
Release of prostaglandins and histamine from sensitized and anaphylactic guinea pig lungs--changes in cyclic AMP levels
Allergy and Asthma
Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.
This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.