PMID: 6412795Sep 10, 1983Paper

Effect on intra-arterial blood pressure of slow release metoprolol combined with placebo or chlorthalidone

British Medical Journal
H A KiesoE B Raftery

Abstract

Thirty patients with essential hypertension participated in a double blind crossover trial in which they were randomly allocated to treatment with either once daily slow release metoprolol (200 mg) with placebo or once daily slow release metoprolol (200 mg) with chlorthalidone (25 mg). Ambulatory intra-arterial blood pressure was recorded continuously for 24-48 hours before treatment and two months after each change in regimen. The response of blood pressure and pulse rate to a standard exercise protocol that included supine rest and tilt, isometric, and dynamic bicycle exercise was measured during the same recording periods. Both treatments appreciably reduced blood pressure and pulse rate; mean daytime intra-arterial blood pressure was reduced from 174/95 mm Hg to 158/85 mm Hg by metoprolol plus placebo and to 143/78 mm Hg by metoprolol plus chlorthalidone. This reduction with the combined treatment was significantly greater than with metoprolol and placebo (p systolic = 0.001, p diastolic = 0.004). Mean night time pressures were reduced from 148/78 mm Hg to 139/75 mm Hg by metoprolol plus placebo and to 116/61 mm Hg by metoprolol plus chlorthalidone. Again the reduction in blood pressure was significantly greater with combin...Continue Reading

References

Apr 15, 1978·Lancet·M W Millar-CraigE B Raftery
Sep 27, 1979·The New England Journal of Medicine·J Koch-Weser
Nov 1, 1978·Medical & Biological Engineering & Computing·M W Millar-CraigJ Whittington
Sep 1, 1979·Medical & Biological Engineering & Computing·P M CashmanM W Craig
Jan 27, 1979·British Medical Journal·M W CraigE B Raftery
Jul 1, 1979·British Journal of Clinical Pharmacology·M Hills, P Armitage
Jan 25, 1969·British Medical Journal·A M Porter
Aug 1, 1981·British Journal of Clinical Pharmacology·S MannE B Raftery
May 1, 1983·Journal of Cardiovascular Pharmacology·B A GouldE B Raftery
Jan 1, 1982·Circulation·B A GouldE B Raftery
Sep 1, 1981·British Journal of Clinical Pharmacology·E B RafteryJ R Whittington

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Citations

Mar 9, 1985·British Medical Journal·E O'BrienK O'Malley
Sep 1, 1996·Journal of Cardiovascular Pharmacology·A J VoogelG A van Montfrans
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Jenny Mh ChenJames M Wright

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