PMID: 8960702Nov 1, 1996Paper

Effect on phloridzin on net rate of liquid absorption from the pleural space of rabbits

Experimental Physiology
L ZocchiA Raffaini

Abstract

Previous indirect findings have suggested the occurrence of solute-coupled liquid absorption from the pleural space, consistent with Na(+)-K(+)-ATPase on the interstitial side plus a Na(+)-H+ and CI(-)-HCO3- double exchange on the luminal side of the pleural mesothelium. To assess whether Na(+)-glucose cotransport also operates on the luminal side, the relationship between net rate of liquid absorption from the right pleural space (Jnet) and volume of liquid injected into this space (0.5, 1 or 2 ml) was determined in anaesthetized rabbits during hydrothoraces with phloridzin (10(-3)M) or with phloridzin plus 4-acetamido-4'-isothiocyanatostilbene-2, 2'-disulphonic acid (SITS; 1.5 x 10(-4)M). The relationship obtained during hydrothoraces with phloridzin was displaced downwards by 0.09 ml h-1 relative to that in control hydrothoraces (P < 0.01). The decrease in Jnet was similar in hydrothoraces of various sizes. The relationship obtained in hydrothoraces with phloridzin plus SITS was displaced downwards by 0.16 ml h-1 relative to that in control hydrothoraces (P < 0.01), i.e. the decrease in Jnet was similar to the sum (0.17 ml h-1) of the decreases in Jnet produced individually by phloridzin and by SITS (0.08 ml h-1). The decrea...Continue Reading

Citations

Jul 27, 2007·Respiratory Physiology & Neurobiology·Chiara SironiEmilio Agostoni
Feb 13, 2004·FEBS Letters·Giuliano MeyerMarkus Paulmichl
Mar 27, 2004·Physiological Reviews·Stephen J Lai-Fook
Jul 11, 2014·Frontiers in Physiology·Alexander G Markov, Salah Amasheh
Dec 14, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·Francesca BodegaEmilio Agostoni
Aug 4, 1998·Journal of Applied Physiology·L ZocchiD Cremaschi
May 29, 2015·Current Opinion in Pulmonary Medicine·Sotirios G Zarogiannis, Ioannis Kalomenidis

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