PMID: 11902610Mar 21, 2002Paper

Effect on prostaglandin E2 and leukotriene B4 levels by local administration of glucocorticoid in human masseter muscle myalgia

Acta Odontologica Scandinavica
B Hedenberg-MagnussonS Kopp

Abstract

Our aim was to determine whether masseter muscle (M) and plasma (P) levels of prostaglandin E2 (PGE2) or leukotriene B4 (LTB4) are influenced by local glucocorticoid administration and whether such changes would be associated with corresponding changes in local pain or hyperalgesia. Eighteen patients with fibromyalgia and 15 with local masseter myalgia were examined immediately before and 2 weeks after intramuscular administration of glucocorticoid with regard to masseter muscle resting pain and tenderness to palpation, pressure pain threshold, maximum voluntary mouth opening (MVM), and pain on maximum voluntary mouth opening. The primary criteria for inclusion were presence of pain for a period of at least 3 months and tenderness to digital palpation in the masseter muscle region. At both visits microdialysis samples were obtained from the masseter muscle, and venous blood was collected for analysis of PGE2 and LTB4. Dialysate levels of M-PGE2 did not change significantly after glucocorticoid administration, but reduction of masseter resting pain and increase of MVM were associated with decrease of M-PGE2 in the patients with fibromyalgia. Dialysate levels of M-LTB4 increased in both groups. In the patients with local myalgia ...Continue Reading

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Feb 8, 2002·Acta Odontologica Scandinavica·B Hedenberg-MagnussonS Kopp

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Citations

Oct 13, 2006·Rheumatology International·Füsum ArdiçAli Gökgöz
Sep 5, 2008·Arthritis Research & Therapy·Dina DadabhoyDaniel J Clauw
Jan 5, 2005·European Journal of Pain : EJP·Maria Cláudia G OliveiraCláudia Herrera Tambeli
Jan 6, 2011·Journal of Internal Medicine·I Loell, I E Lundberg
Jan 19, 2012·Journal of Oral Rehabilitation·D L BasiL J Kehl
Nov 26, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Cynthia R Sides, Julie A Stenken
Mar 13, 2012·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Giacomo M GuidelliAntonella Fioravanti
May 1, 2021·Journal of Clinical Medicine·Chun-Feng CaoHai-Qiang Wang

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