Effect on the offspring of pregnant females CD-1 mice treated with a single thallium(I) application

Reproductive Toxicology
Lucila Álvarez-BarreraMario A Altamirano-Lozano

Abstract

Thallium (Tl) is a highly toxic metal for human beings; higher amounts found in diverse fluids of pregnant women are associated with low birth weight and preterm birth. However, experimental data concerning their effects on the embryonic development of mammalian organisms are limited. Hence, in the present work, TI(I) acetate of 0, 4.6, 9.2, or 18.5 mg/kg body weight were administered by intraperitoneal injection to groups of 10 pregnant CD-1 mice on the 7th gestational day, and animals were sacrificed on day 18 of gestation. The fetuses obtained showed some variations, such as trunk bent over (18.5 mg/kg), tail variations (all doses), forelimbs malrotation and hind limbs (all doses). Skeletal examination of the fetuses showed a delay in the ossification of skull bones, ribs, and limbs (all doses). In conclusion, the Intraperitoneal injection of Tl(I) acetate to pregnant mice induced morphological variations and a delay of the fetus ossification.

Citations

May 23, 2021·Environmental Science and Pollution Research International·Wen Zhuang, Jinming Song
Jun 4, 2021·Archives of Environmental & Occupational Health·Xiaochen MaJing Liu
Sep 4, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·A M VarãoP Gubert

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