PMID: 8607664Apr 1, 1996Paper

Effective 30-hour preservation of canine lungs with modified ET-Kyoto solution

The Annals of Thoracic Surgery
H WadaS Kosaka

Abstract

With the aim of developing a preservation solution that can preserve donor lungs reliably for a long time, we prepared a modified ET-Kyoto solution by adding N-acetylcysteine, nitroglycerin, and dibutyryl adenosine 3', 5'-cyclic phosphate to the previously reported ET-Kyoto solution, which contains trehalose, gluconate, and hydroxyethyl starch. In this study, we examined the efficacy of modified ET-Kyoto solution in 30-hour lung preservation. Twenty five pairs of adult mongrel dogs were divided into four groups. Donor lungs were flushed with modified ET-Kyoto solution (n = 9), with ET-Kyoto solution (n = 6), with University of Wisconsin solution group (n = 6), or with ET-Kyoto solution plus the solvents of nitroglycerin (ethanol and propylene glycol) (n = 4), then stored at 4 degrees C for 30 hours. All animals were treated with prostaglandin E1. Left lungs were transplanted and reperfused for 6 hours. With respect to arterial oxygen tension, peak inspiratory pressure, and wet-to-dry lung weight ratio, modified ET-Kyoto solution was significantly superior to ET-Kyoto solution. The modified ET-Kyoto solution was significantly superior to University of Wisconsin solution with respect to survival rate, arterial oxygen tension, and...Continue Reading

References

Feb 1, 1990·Transplantation·J H SouthardF O Belzer
Aug 1, 1989·The American Review of Respiratory Disease·J E Heffner, J E Repine
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·D J PinskyD M Stern

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Citations

Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·M KawashimaH Wada
Feb 22, 2002·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Shinji KosakaHiromi Wada
Jan 18, 2008·ANZ Journal of Surgery·Themistocles P ChamogeorgakisIoannis K Toumpoulis
May 23, 2014·Surgery Today·Masaki IkedaHiroshi Date
Mar 1, 2000·The Journal of Thoracic and Cardiovascular Surgery·S FischerS Keshavjee
Oct 24, 1997·The Journal of Thoracic and Cardiovascular Surgery·T NakamuraH Wada
Sep 17, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Naozumi TeramotoMitsuhiro Shibata
Dec 22, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·R L FeatherstoneD J Chambers
Jul 31, 1999·Transplantation·T FukuseH Wada
Jun 6, 2019·International Journal of Molecular Sciences·Atsushi FujiwaraHiroyasu Yokomise

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