Effective accumulation of poly(vinylpyrrolidone-co-vinyl laurate) into the spleen

Journal of Biomedical Materials Research. Part a
Yasuo YoshiokaT Mayumi

Abstract

To optimize polymer-conjugated drugs as a polymeric drug delivery system, it is essential to design polymeric carriers with tissue-specific targeting capacity. Previously, we showed that polyvinylpyrrolidone (PVP) was the most suitable polymeric carrier for prolonging the blood-residency of drugs, and was one of the best parent polymers to design the polymeric carriers with targeting capacity. In this study, we synthesized some hydrophobic PVP derivatives, poly(vinylpyrrolidone-co-styrene) [poly(VP-co-S)] and poly(vinylpyrrolidone-co-vinyl laurate) [poly(VP-co-VL)], and assessed their biopharmaceutical properties after intravenous administration in mice. The elimination of hydrophobic PVP derivatives from blood was the same as PVP, and the plasma half-lives of poly(VP-co-S) were almost similar to that of poly(VP-co-VL). Poly(VP-co-VL) efficiently accumulated in the spleen, whereas poly(VP-co-S) effectively accumulated in the liver. The level of poly(VP-co-VL) in the spleen was about 20 times higher than PVP and poly(VP-co-S). These hydrophobic PVP derivatives did not show any cytotoxicity against endothelial cells in vitro. Thus, poly(VP-co-VL) may be a useful polymeric carrier for drug delivery to the spleen. This study will p...Continue Reading

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Citations

Dec 2, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yusuke EtoShinsaku Nakagawa
Mar 18, 2006·Journal of Photochemistry and Photobiology. B, Biology·William Wei Lim ChinMalini Olivo
Jan 5, 2006·Pharmaceutical Research·Li Yan Qiu, You Han Bae
Nov 2, 2006·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·William Wei Lim ChinMalini Olivo
Oct 21, 2016·Physiological Research·E Böhmová, R Pola

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