Abstract
Tramadol and tapentadol are extensively prescribed for the treatment of moderate to severe pain. Although these drugs are very effective in pain treatment, the number of intoxications and deaths due to both opioids is increasing, and the underlying toxic mechanisms are not fully understood. The present work aimed to study the potential biochemical and histopathological alterations induced by acute effective (analgesic) doses of tramadol and tapentadol, in Wistar rats. Forty-two male Wistar rats were divided into different groups: a control, administered with normal saline solution, and tramadol- or tapentadol-treated groups (10, 25 or 50mg/kg - typical effective analgesic dose, intermediate and maximum recommended doses, respectively). 24h after intraperitoneal administration, biochemical and oxidative stress analyses were performed in blood, and specimens from brain, lung and heart were taken for histopathological and oxidative stress studies. Both drugs caused an increase in the AST/ALT ratio, in LDH, CK and CK-MB activities in serum samples, and an increase in lactate levels in serum and brain samples. Oxidative damage, namely protein oxidation, was found in heart and lung tissues. In histological analyses, tramadol and tape...Continue Reading
Citations
Jan 26, 2018·European Journal of Pain : EJP·J FariaR J Dinis-Oliveira
Feb 18, 2020·Journal of Liposome Research·Mamta BishnoiBirendra Shrivastava
May 23, 2020·Journal of Molecular Neuroscience : MN·Haytham A AliAmmar Al-Farga
Jul 2, 2019·Human & Experimental Toxicology·M SavranY Sahin
Jun 2, 2020·Expert Opinion on Drug Metabolism & Toxicology·Mohsen Doostmohammadi, Hamid-Reza Rahimi
Apr 17, 2020·Expert Review of Clinical Pharmacology·Samaneh NakhaeeOmid Mehrpour
Mar 29, 2020·BioMed Research International·Fatma M MinisyHisashi Oishi
Jul 10, 2018·European Heart Journal·Péter FerdinandyRainer Schulz
Jul 16, 2020·Pharmaceuticals·Joana BarbosaRicardo Jorge Dinis-Oliveira
Jan 31, 2021·Pharmaceuticals·Joana BarbosaRicardo Jorge Dinis-Oliveira
Dec 5, 2020·Journal of Chemical Neuroanatomy·Ghada Abdel KaderZinab Abdel-Hady
Mar 2, 2021·Journal of Biochemical and Molecular Toxicology·Omaima I Abdel HamidSahar F Shaban
Jul 22, 2021·Heliyon·A F Ajayi, R E Akhigbe
Jul 2, 2021·Drugs·Lucien RouletValérie Piguet