Effective analgesic doses of tramadol or tapentadol induce brain, lung and heart toxicity in Wistar rats

Toxicology
Juliana FariaR J Dinis-Oliveira

Abstract

Tramadol and tapentadol are extensively prescribed for the treatment of moderate to severe pain. Although these drugs are very effective in pain treatment, the number of intoxications and deaths due to both opioids is increasing, and the underlying toxic mechanisms are not fully understood. The present work aimed to study the potential biochemical and histopathological alterations induced by acute effective (analgesic) doses of tramadol and tapentadol, in Wistar rats. Forty-two male Wistar rats were divided into different groups: a control, administered with normal saline solution, and tramadol- or tapentadol-treated groups (10, 25 or 50mg/kg - typical effective analgesic dose, intermediate and maximum recommended doses, respectively). 24h after intraperitoneal administration, biochemical and oxidative stress analyses were performed in blood, and specimens from brain, lung and heart were taken for histopathological and oxidative stress studies. Both drugs caused an increase in the AST/ALT ratio, in LDH, CK and CK-MB activities in serum samples, and an increase in lactate levels in serum and brain samples. Oxidative damage, namely protein oxidation, was found in heart and lung tissues. In histological analyses, tramadol and tape...Continue Reading

Citations

Jan 26, 2018·European Journal of Pain : EJP·J FariaR J Dinis-Oliveira
May 23, 2020·Journal of Molecular Neuroscience : MN·Haytham A AliAmmar Al-Farga
Jun 2, 2020·Expert Opinion on Drug Metabolism & Toxicology·Mohsen Doostmohammadi, Hamid-Reza Rahimi
Apr 17, 2020·Expert Review of Clinical Pharmacology·Samaneh NakhaeeOmid Mehrpour

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