Effective bladder sparing therapy with intra-arterial cisplatin and radiotherapy for localized bladder cancer

The Journal of Urology
Libni EapenRebecca Peterson

Abstract

We evaluated the feasibility and efficacy of the organ preserving strategy of intra-arterial cisplatin and concurrent radiotherapy for localized bladder cancer. Bladder preservation has been pursued over the decades in treatment regimens featuring radiotherapy alone or in conjunction with single or multiagent chemotherapy. The chemotherapy has consisted almost exclusively of intravenously administered drugs. There are theoretical and clinical data demonstrating a higher concentration of cisplatin within tumors following intra-arterial as opposed to intravenous delivery. This study was performed to evaluate whether this increased concentration would enhance radiosensitization and thereby increase the success of bladder preservation. We report on our prospectively collected experience during 15 years of treating 200 patients with localized bladder cancer using this regimen of 3 courses of intra-arterial cisplatin integrated with pelvic radiotherapy and reserving cystectomy for salvage as required. We report on the efficacy in terms of complete response rate, ultimate tumor-free bladder preservation, overall survival and patterns of failure. We detail the acute and chronic toxicity observed to date. This strategy has resulted in a...Continue Reading

References

Sep 11, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C Y FungG R Prout
Feb 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L EapenL Gerig
Dec 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W Duncan, P M Quilty
Sep 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·A H Nias
Dec 1, 1980·British Journal of Urology·J P BlandyR A Risdon
Nov 4, 1993·The New England Journal of Medicine·D S KaufmanJ T Efird
Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W TesterW Shipley

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Citations

Nov 4, 2006·World Journal of Urology·Jason A EfstathiouWilliam U Shipley
Jul 12, 2012·Japanese Journal of Clinical Oncology·Mizuki OnozawaHideyuki Akaza
Aug 13, 2009·Current Oncology·N J ReneL Souhami
Sep 24, 2014·Surgical Oncology Clinics of North America·Bruno C Odisio, Michael J Wallace
Dec 3, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S BellefqihN Benjaafar
Nov 28, 2008·BJU International·Raymond H MakWilliam U Shipley
Jul 25, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Ken-ichi MoriHiroshi Kanetake
Mar 14, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Fumitaka Koga, Kazunori Kihara
Nov 15, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Haruhito AzumaTakanobu Ubai
Dec 24, 2005·Clinical Oncology : a Journal of the Royal College of Radiologists·A MambriniM Cantore
Jan 6, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ananya ChoudhuryRichard A Cowan
Sep 9, 2020·Japanese Journal of Clinical Oncology·Tomokazu KimuraHiroyuki Nishiyama
Jul 1, 2018·Current Oncology Reports·Skyler B Johnson, James B Yu
Nov 25, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Teruo InamotoHaruhito Azuma
Jun 13, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jonathan KhalifaPaul Sargos

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