Effective blockade of RAAS by combination of aliskiren and olmesartan improves glucose homeostasis, glomerular filtration rate along with renal variables in streptozotocin induced diabetic rats

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Sonia GandhiAtul Sureshrao Akarte

Abstract

The present study aims to investigate the combined and individual treatment of aliskiren and olmesartan for 8 weeks in streptozotocin induced diabetic rats provide an effective blockade of RAAS by improving glucose homeostasis, glomerular filtration rate along with renal variables thereby delaying the progression of the disease. Streptozotocin induced diabetic rats were administered with aliskiren (10mg/kg/day), olmesartan (6mg/kg/day) alone and in combination. To identify the glucose homeostasis, translocation of glucose transporter proteins in liver and muscle was observed by their expression after treatment. Glomerular filtration rate is estimated using serum creatinine, cystatin C and beta 2 microglobulin. This study also examined the effects of combination and monotherapy on various renal variables viz. albumin, total proteins, TGF-β, TNF-α, VEGF, nitric oxide, adiponectin and erythropoeitin. In addition, histopathological and anti-apoptotic profile of kidney was also investigated. The present study indicates that dual blockade of RAAS improved glucose homeostasis and confirms the nephroprotective effects of the combined treatment of aliskiren and olmesartan independent of their antihypertensive property in the STZ induced...Continue Reading

References

Jan 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A S Woolf, L G Fine
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·N Casadevall
Aug 1, 1996·Scandinavian Journal of Clinical and Laboratory Investigation·O TenstadK Aukland
Feb 1, 1997·Transplantation Proceedings·T MatsunoN Tanaka
Nov 30, 1999·Journal of the American Society of Nephrology : JASN·D A PriceN K Hollenberg
Jan 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Iain C Macdougall, Angela Cooper
Feb 2, 2002·Clinical Pharmacology and Therapeutics·Marc P MaillardHans R Brunner
Dec 24, 2002·Current Opinion in Nephrology and Hypertension·Genevieve NguyenJean-Daniel Sraer
Jan 14, 2003·Experimental Biology and Medicine·James W Fisher
Feb 4, 2003·Nature Medicine·Daniel L Kaufman
Apr 16, 2003·Kidney International. Supplement·George A Kaysen, Burl R Don
Sep 1, 1957·The Journal of Experimental Medicine·L T SKEGGSN P SHUMWAY
Nov 12, 2003·The New England Journal of Medicine·Douglas L Mann, Anita Deswal
Oct 14, 2004·Laboratory Animals·Biji T KurienR Hal Scofield
Feb 3, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Robert C AtkinsEdmund J Lewis
Mar 25, 2005·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Rajesh SubramanianEvgeny Shalman
Mar 31, 2005·Biochemical and Biophysical Research Communications·Toshiyo SontaHajime Nawata
Aug 18, 2005·European Heart Journal·Ruud M A van de WalAdriaan A Voors
Oct 13, 2005·Journal of Cardiovascular Pharmacology·David E MireMichael K Pugsley
Feb 3, 2006·The Journal of Clinical Investigation·Giuseppe RemuzziAndrea Remuzzi
Oct 13, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·UNKNOWN International Federation of Clinical Chemistry and Laboratory MedicineNeil Greenberg
Feb 27, 2007·Diabetes Research and Clinical Practice·Jan Ostergren
Apr 27, 2007·Biochimica Et Biophysica Acta·Laurent GelmanBéatrice Desvergne
May 3, 2007·Biological & Pharmaceutical Bulletin·Yoshihiko HirotaniNobuo Kurokawa
May 24, 2007·Critical Care : the Official Journal of the Critical Care Forum·José David Herrero-MorínAlberto Medina
Jul 4, 2007·Circulation·Ernesto L SchiffrinJohannes F E Mann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Young Sun KangDae Ryong Cha
Current Hypertension Reports
Rekha Pinto, Alan H Gradman
© 2022 Meta ULC. All rights reserved