PMID: 6171334Dec 15, 1981Paper

Effective chemotherapy for esophageal cancer with methotrexate, bleomycin, and cis-diamminedichloroplatinum II

Cancer
S E VoglB H Kaplan

Abstract

Ten patients with squamous cancer of the esophagus were treated with an outpatient regimen combining cis-diamminedichloroplatinum (II), methotrexate and bleomycin. Nine of these had metastatic disease or recurrence after radiotherapy. Objective responses were noted in 50%, regardless of performance status or metastatic site. None of three patients with prior radiation therapy responded, however. Median duration of response was six months. Responders survived a median of eight months versus five months for nonresponders. Three patients had severe hematologic toxicity. A single patient with massive disease confined to the esophagus had an excellent response to six weeks of chemotherapy before radical irradiation. He is disease-free after two years but is paraplegic from radiation myelitis. This chemotherapy program is an effective palliative therapy for metastatic esophageal cancer. Its safety and efficacy as part of the initial treatment of local disease should be further investigated.

Citations

Feb 10, 2010·American Journal of Clinical Oncology·Hyun-Jeong ShimIk-Joo Chung
Mar 1, 1997·Cancer Treatment Reviews·T C Kok
Oct 1, 1985·Cancer·S H AdvaniP B Desai
Jan 1, 1985·European Journal of Cancer & Clinical Oncology·D Kelsen
Feb 15, 1984·Postgraduate Medicine·F H Ellis
Jan 1, 1985·Seminars in Surgical Oncology·P B DesaiV S Swaroop

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